Granulocyte colony-stimulating factor off-target effect on nerve outgrowth promotes prostate cancer development

Kostantin Dobrenis, Laurent R. Gauthier, Vilma Barroca, Claire Magnon

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The hematopoietic growth factor granulocyte colony-stimulating factor (G-CSF) has a role in proliferation, differentiation and migration of the myeloid lineage and in mobilizing hematopoietic stem and progenitor cells into the bloodstream. However, G-CSF has been newly characterized as a neurotrophic factor in the brain. We recently uncovered that autonomic nerve development in the tumor microenvironment participates actively in prostate tumorigenesis and metastasis. Here, we found that G-CSF constrains cancer to grow and progress by, respectively, supporting the survival of sympathetic nerve fibers in 6-hydroxydopamine-sympathectomized mice and also, promoting the aberrant outgrowth of parasympathetic nerves in transgenic or xenogeneic prostate tumor models. This provides insight into how neurotrophic growth factors may control tumor neurogenesis and may lead to new antineurogenic therapies for prostate cancer.

Original languageEnglish (US)
Pages (from-to)982-988
Number of pages7
JournalInternational Journal of Cancer
Volume136
Issue number4
DOIs
StatePublished - Feb 15 2015

Keywords

  • Autonomic nervous system
  • G-CSF
  • Hematopoietic cytokine
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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