Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial

Stephen G. Ellis, Marc S. Penn, Brian Bolwell, Mario Garcia, Matthews Chacko, Thomas Wang, Kelly J. Brezina, Gerry McConnell, Eric J. Topol

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Background: Preclinical studies suggest that administration of cytokines to mobilize stem cells and alter the postinfarction inflammatory cardiac milieu may enhance left ventricular function and survival. Methods: Eighteen patients were randomized in a 2:1 double-blind fashion to granulocyte colony stimulating factor (G-CSF) (at 5 escalating to 10 μg/kg per day subcutaneously for 5 days [6 patients in each group]) or matching placebo. Principal safety and efficacy end points were rupture-free survival and recovery of left ventricular function, respectively. Mobilization into the systemic circulation of precursor CD34+ and CD117+ stem cells at 30 days were also assessed. Results: Baseline characteristics of the 3 groups were well matched. Mean ± SD creatine kinase-MB maximum was 349 (169) IU. Follow-up averaged 30 ± 6, 21 ± 11, and 11 ± 6 months in the 3 groups, respectively. Precursor cell mobilization increased by a factor of 5 to 7 in the G-CSF-treated patients. There were no deaths or myocardial ruptures leading to tamponade through 30 days. Baseline and 30-day left ventricular ejection fraction in the placebo, 5-μg, and 10-μg dose groups were 33.7% (1.6) and 41.7% (8.2), 36.8% (7.5) and 41.3% (10.3), and 33.5% (4.8) and 38.7% (7.3), respectively (P = NS for all between-group comparisons). No differences between the G-CSF and placebo groups were noted in any other measure of left ventricular systolic or diastolic function 30 days after infarction. Conclusions: Despite demonstrated mobilization of precursor stem cells in a timely fashion, in this small, pilot-scale randomized trial involving patients with large myocardial infarction, we were unable to demonstrate improvement in left ventricular function at 30 days.

Original languageEnglish (US)
Pages (from-to)1051.e9-1051.e14
JournalAmerican heart journal
Volume152
Issue number6
DOIs
StatePublished - Dec 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ellis, S. G., Penn, M. S., Bolwell, B., Garcia, M., Chacko, M., Wang, T., Brezina, K. J., McConnell, G., & Topol, E. J. (2006). Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial. American heart journal, 152(6), 1051.e9-1051.e14. https://doi.org/10.1016/j.ahj.2006.09.003