GPR30: a novel indicator of poor survival for endometrial carcinoma

Harriet O. Smith, Kimberly K. Leslie, Meenakshi Singh, Clifford R. Qualls, Chetana M. Revankar, Nancy E. Joste, Eric R. Prossnitz

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

Objective: This study was undertaken to evaluate the relationship between GPR30, classical steroidal receptor expression, and clinical outcome in patients with endometrial carcinoma. Study Design: Immunohistochemistry was used to investigate the expression of GPR30, estrogen, progesterone, epidermal growth factor receptors and Ki-67 in 47 consecutive consenting patients with endometrial carcinoma diagnosed between 1997 and 2001. Results were correlated with clinical and pathologic predictors of adverse outcome and survival. Results: GPR30 correlated positively with epidermal growth factor receptor (P = .005), but negatively with progesterone (P = .05) receptor expression. GPR30 overexpression occurred more frequently in tumors with deep myometrial invasion, high-grade, biologically aggressive histologic subtypes, and advanced stage. In patients with GPR30 overexpression, survival was significantly poorer (65.2% vs 100%, P = .005). Conclusion: GPR30 represents an alternative estrogen-responsive receptor that is overexpressed in tumors where estrogen and progesterone receptors are downregulated, and in high-risk endometrial cancer patients with lower survival rates.

Original languageEnglish (US)
Pages (from-to)386.e1-386.e11
JournalAmerican journal of obstetrics and gynecology
Volume196
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • GPR30
  • endometrial carcinoma
  • estrogen receptor
  • progesterone receptor
  • survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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