Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels

R. T. Scott, E. H. Illions, K. D. Carey, D. Navot

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of gonadotropin levels. This indicates that GnRH antagonists fundamentally alter gonadotrope response mechanisms without inhibiting gonadotropin release. Beyond the physiologic implications, these data may eventually impact the development of clinical protocols. Benefits could include enhancements in the endogenous gonadotropin flare during controlled ovarian hyperstimulation cycles. Additionally, proposed contraceptive protocols where GnRH antagonists are used to produce the initial inhibition in gonadotropin release and are then followed by a GnRH-a (to avoid the gonadotropin flare) may in fact produce paradoxical results.

Original languageEnglish (US)
Pages (from-to)1069-1071
Number of pages3
JournalFertility and Sterility
Volume62
Issue number5
Publication statusPublished - Jan 1 1994

    Fingerprint

Keywords

  • Gonadotropin-releasing hormone
  • baboon
  • gonadotropes
  • gonadotropin-releasing hormone antagonists
  • gonadotropins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this