Abstract
Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 254-257 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Gonadotropin dynamics in xx males. / Pérez-Palacios, Gregorio; Medina, Martha; Ullao-Aguirre, Alfredo; Chávez, Beftha A.; Villareal, Guillerom; Dutrem, Teresa M.; Cahill, Linda Theill; Wachtel, Stephen.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 53, No. 2, 01.01.1981, p. 254-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gonadotropin dynamics in xx males
AU - Pérez-Palacios, Gregorio
AU - Medina, Martha
AU - Ullao-Aguirre, Alfredo
AU - Chávez, Beftha A.
AU - Villareal, Guillerom
AU - Dutrem, Teresa M.
AU - Cahill, Linda Theill
AU - Wachtel, Stephen
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.
AB - Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.
UR - http://www.scopus.com/inward/record.url?scp=0019737781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019737781&partnerID=8YFLogxK
U2 - 10.1210/jcem-53-2-254
DO - 10.1210/jcem-53-2-254
M3 - Article
VL - 53
SP - 254
EP - 257
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -