Gonadotropin dynamics in xx males

Gregorio Pérez-Palacios; Martha Medina; Alfredo Ullao-Aguirre; Beftha A. Chávez; Guillerom Villareal; Teresa M. Dutrem; Linda T. Cahill; Stephen Wachtel

doi:10.1210/jcem-53-2-254

Gonadotropin dynamics in xx males

Gregorio Pérez-Palacios, Martha Medina, Alfredo Ullao-Aguirre, Beftha A. Chávez, Guillerom Villareal, Teresa M. Dutrem, Linda T. Cahill, Stephen Wachtel

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.

Original language	English (US)
Pages (from-to)	254-257
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	53
Issue number	2
DOIs	https://doi.org/10.1210/jcem-53-2-254
State	Published - Aug 1981

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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title = "Gonadotropin dynamics in xx males",

abstract = "Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.",

author = "Gregorio P{\'e}rez-Palacios and Martha Medina and Alfredo Ullao-Aguirre and Ch{\'a}vez, {Beftha A.} and Guillerom Villareal and Dutrem, {Teresa M.} and Cahill, {Linda T.} and Stephen Wachtel",

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doi = "10.1210/jcem-53-2-254",

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AU - Pérez-Palacios, Gregorio

AU - Medina, Martha

AU - Ullao-Aguirre, Alfredo

AU - Chávez, Beftha A.

AU - Villareal, Guillerom

AU - Dutrem, Teresa M.

AU - Cahill, Linda T.

AU - Wachtel, Stephen

PY - 1981/8

Y1 - 1981/8

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AB - Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.

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