Gonadotropin dynamics in xx males

Gregorio Pérez-Palacios; Martha Medina; Alfredo Ullao-Aguirre; Beftha A. Chávez; Guillerom Villareal; Teresa M. Dutrem; Linda T. Cahill; Stephen Wachtel

doi:10.1210/jcem-53-2-254

Gonadotropin dynamics in xx males

Gregorio Pérez-Palacios, Martha Medina, Alfredo Ullao-Aguirre, Beftha A. Chávez, Guillerom Villareal, Teresa M. Dutrem, Linda T. Cahill, Stephen Wachtel

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5 Scopus citations

Abstract

Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.

Original language	English (US)
Pages (from-to)	254-257
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	53
Issue number	2
DOIs	https://doi.org/10.1210/jcem-53-2-254
Publication status	Published - Aug 1981
Externally published	Yes

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ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

Cite this

Pérez-Palacios, G., Medina, M., Ullao-Aguirre, A., Chávez, B. A., Villareal, G., Dutrem, T. M., ... Wachtel, S. (1981). Gonadotropin dynamics in xx males. Journal of Clinical Endocrinology and Metabolism, 53(2), 254-257. https://doi.org/10.1210/jcem-53-2-254

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AU - Pérez-Palacios, Gregorio

AU - Medina, Martha

AU - Ullao-Aguirre, Alfredo

AU - Chávez, Beftha A.

AU - Villareal, Guillerom

AU - Dutrem, Teresa M.

AU - Cahill, Linda T.

AU - Wachtel, Stephen

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AB - Hypothalamic-pituitary gonadotropin function was evaluated in two postpubertal XX males. Serum levels of LH and FSH were moderately elevated, and the serum testosterone level was low. A subnormal response by testicular Leydig cells to hCG was observed. The LH and FSH responses to LRH were normal. A significant LH increase was observed after castration. Weekly administration of testosterone enanthate (250 mg) for 10 consecutive weeks caused a reduction (>75%) in gonadotropins and abolishment of the LRH pituitary response. No differences were observed in terms of gonadotropin dynamics compared with other forms of hypergonadotropic hypogonadism. These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit.

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10.1210/jcem-53-2-254