Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

Theodore Nagel; Mauricio Camargo; George Tagatz; Takashi Okagaki; Jaroslav Cervenka; Linda Cahill; Stephen S. Wachtel; Richard King; Leo B. Twiggs

doi:10.1016/S0002-9378(84)80113-1

Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

Theodore Nagel, Mauricio Camargo, George Tagatz, Takashi Okagaki, Jaroslav Cervenka, Linda Cahill, Stephen S. Wachtel, Richard King, Leo B. Twiggs

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xg^a and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

Original language	English (US)
Pages (from-to)	76-82
Number of pages	7
Journal	American journal of obstetrics and gynecology
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/S0002-9378(84)80113-1
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/S0002-9378(84)80113-1

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title = "Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments",

abstract = "Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.",

author = "Theodore Nagel and Mauricio Camargo and George Tagatz and Takashi Okagaki and Jaroslav Cervenka and Linda Cahill and Wachtel, {Stephen S.} and Richard King and Twiggs, {Leo B.}",

note = "Funding Information: From the Departments of Obstetrics and Gynecology, Oral Pathology and Genetics, and Internal Medicine, University of Minnesota School of Medicine, and the Division of Pediatric Endocrinology, Cornell University Medical College. Supported in part iJy grants from the Dwight School Foundation, National Institutes of Health Grants AI 19456 and HD-17049, and March of Dimes Grant No. 6-264. Received for publication November 9, 1983; revised January 27, 1984; accepted March 26, 1984. Reprint requests: Dr. Theodore Nagel, Department of Obstetrics and Gynecology, Box 395 Mayo, University of Minnesota, Min-neapolis, MN 55455.",

year = "1984",

doi = "10.1016/S0002-9378(84)80113-1",

language = "English (US)",

volume = "150",

pages = "76--82",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

AU - Nagel, Theodore

AU - Camargo, Mauricio

AU - Tagatz, George

AU - Okagaki, Takashi

AU - Cervenka, Jaroslav

AU - Cahill, Linda

AU - Wachtel, Stephen S.

AU - King, Richard

AU - Twiggs, Leo B.

N1 - Funding Information: From the Departments of Obstetrics and Gynecology, Oral Pathology and Genetics, and Internal Medicine, University of Minnesota School of Medicine, and the Division of Pediatric Endocrinology, Cornell University Medical College. Supported in part iJy grants from the Dwight School Foundation, National Institutes of Health Grants AI 19456 and HD-17049, and March of Dimes Grant No. 6-264. Received for publication November 9, 1983; revised January 27, 1984; accepted March 26, 1984. Reprint requests: Dr. Theodore Nagel, Department of Obstetrics and Gynecology, Box 395 Mayo, University of Minnesota, Min-neapolis, MN 55455.

PY - 1984

Y1 - 1984

N2 - Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

AB - Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

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AN - SCOPUS:0021259810

SN - 0002-9378

VL - 150

SP - 76

EP - 82

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

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ER -

Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

Abstract

ASJC Scopus subject areas

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