Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

Theodore Nagel, Mauricio Camargo, George Tagatz, Takashi Okagaki, Jaroslav Cervenka, Linda Theill Cahill, Stephen S. Wachtel, Richard King, Leo B. Twiggs

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume150
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Gonadal Dysgenesis
Gonads
Cytogenetics
H-Y Antigen
Phenotype
Neoplasms
Germ Cell and Embryonal Neoplasms
DNA Replication
Chromatin
Histology
Hormones

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments. / Nagel, Theodore; Camargo, Mauricio; Tagatz, George; Okagaki, Takashi; Cervenka, Jaroslav; Cahill, Linda Theill; Wachtel, Stephen S.; King, Richard; Twiggs, Leo B.

In: American Journal of Obstetrics and Gynecology, Vol. 150, No. 1, 01.01.1984, p. 76-82.

Research output: Contribution to journalArticle

Nagel, T, Camargo, M, Tagatz, G, Okagaki, T, Cervenka, J, Cahill, LT, Wachtel, SS, King, R & Twiggs, LB 1984, 'Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments', American Journal of Obstetrics and Gynecology, vol. 150, no. 1, pp. 76-82. https://doi.org/10.1016/S0002-9378(84)80113-1
Nagel, Theodore ; Camargo, Mauricio ; Tagatz, George ; Okagaki, Takashi ; Cervenka, Jaroslav ; Cahill, Linda Theill ; Wachtel, Stephen S. ; King, Richard ; Twiggs, Leo B. / Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments. In: American Journal of Obstetrics and Gynecology. 1984 ; Vol. 150, No. 1. pp. 76-82.
@article{fe2f855a66e84975b02208b02bf1084a,
title = "Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments",
abstract = "Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.",
author = "Theodore Nagel and Mauricio Camargo and George Tagatz and Takashi Okagaki and Jaroslav Cervenka and Cahill, {Linda Theill} and Wachtel, {Stephen S.} and Richard King and Twiggs, {Leo B.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1016/S0002-9378(84)80113-1",
language = "English (US)",
volume = "150",
pages = "76--82",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Gonadal tumors in patients with gonadal dysgenesis and sex chromosomal rings and fragments

AU - Nagel, Theodore

AU - Camargo, Mauricio

AU - Tagatz, George

AU - Okagaki, Takashi

AU - Cervenka, Jaroslav

AU - Cahill, Linda Theill

AU - Wachtel, Stephen S.

AU - King, Richard

AU - Twiggs, Leo B.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

AB - Patients with female phenotypes and dysgenetic gonads harboring testicular tissue have a markedly increased risk of developing gonadal tumors. Cytogenetic demonstration of Y chromatin is the currently accepted criterion for performing prophylactic gonadectomies in these women. We studied four patients with dysgenetic gonads containing either testicular tissue or germ cell tumors. All had small sex chromosomal fragments which could not be characterized by conventional cytogenetic studies. Clinical features, DNA replication studies, and immunologic assays of Xga and H-Y antigens failed to correlate consistently with the gonadal histology. We recommend prophylactic gonadectomies and subsequent hormone replacement in all patients with female phenotypes, gonadal dysgenesis, and cytogenetically indeterminate sex chromosomal fragments.

UR - http://www.scopus.com/inward/record.url?scp=0021259810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021259810&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(84)80113-1

DO - 10.1016/S0002-9378(84)80113-1

M3 - Article

C2 - 6476029

AN - SCOPUS:0021259810

VL - 150

SP - 76

EP - 82

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -