Glutathione S-transferase M1, T1, and P1 polymorphisms and prostate cancer risk in middle-aged men

Ilir Agalliu, Wendy J. Langeberg, Johanna W. Lampe, Claudia A. Salinas, Janet L. Stanford

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

BACKGROUND. The glutathione S-transferase (GST) enzymes detoxify several carcinogens. Genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been associated with prostate cancer, however, results have been inconsistent across studies. METHODS. Data from a population-based case-control study in King County, Washington, were used to further evaluate the relationships between these GST polymorphisms and prostate cancer. Incident cases (n = 590) were 40-64 years old, diagnosed from 1993 through 1996, and identified via the SEER cancer registry. Controls (n = 538) were identified via random digit dialing, and frequency age-matched to cases. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS. Risk of prostate cancer was moderately increased among Caucasians with the GSTM1-null genotype (OR = 1.54; 95% CI 1.19-2.01). There were no associations for either GSTT1 or P1 (Ile105Val). The association between the GSTM1-null genotype and prostate cancer was not different according to cancer aggressiveness defined by stage at diagnosis and Gleason score. Among GSTM1-null Caucasians, the relative risk of prostate cancer increased linearly with increasing pack-years of smoking (P-value for trend = 0.007), with the highest ORs observed for smokers of >30 pack-years. CONCLUSIONS. Findings suggest that the GSTM1-null genotype defines a subgroup of men at higher risk of prostate cancer, particularly if they are heavy smokers.

Original languageEnglish (US)
Pages (from-to)146-156
Number of pages11
JournalProstate
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Keywords

  • Gene-environment interactions
  • Genetic polymorphisms
  • Glutathione S-transferase
  • Population-attributable risk percent
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

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