GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus

Lawrence P. Reagan, Daniel R. Rosell, Stephen E. Alves, Elena K. Hoskin, Anthony L. McCall, Maureen J. Charron, Bruce S. McEwen

Research output: Contribution to journalArticle

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Abstract

Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (microglial), it appears that GLUT8 is expressed exclusively in neurons. At the cellular level, GLUT8 immunofluorescence was localized to neuronal cell bodies and the most proximal dendrites of inhibitory and excitatory neurons while GLUT3 immunofluorescence was localized to the neuropil in the hippocampus. These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalBrain Research
Volume932
Issue number1-2
DOIs
StatePublished - Apr 5 2002

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Facilitative Glucose Transport Proteins
Hippocampus
Neurons
Fluorescent Antibody Technique
Neuropil
Dendrites
Fluorescence
Immunohistochemistry
Phenotype
Brain

Keywords

  • Glucose transproter

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reagan, L. P., Rosell, D. R., Alves, S. E., Hoskin, E. K., McCall, A. L., Charron, M. J., & McEwen, B. S. (2002). GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. Brain Research, 932(1-2), 129-134. https://doi.org/10.1016/S0006-8993(02)02308-9

GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. / Reagan, Lawrence P.; Rosell, Daniel R.; Alves, Stephen E.; Hoskin, Elena K.; McCall, Anthony L.; Charron, Maureen J.; McEwen, Bruce S.

In: Brain Research, Vol. 932, No. 1-2, 05.04.2002, p. 129-134.

Research output: Contribution to journalArticle

Reagan, LP, Rosell, DR, Alves, SE, Hoskin, EK, McCall, AL, Charron, MJ & McEwen, BS 2002, 'GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus', Brain Research, vol. 932, no. 1-2, pp. 129-134. https://doi.org/10.1016/S0006-8993(02)02308-9
Reagan, Lawrence P. ; Rosell, Daniel R. ; Alves, Stephen E. ; Hoskin, Elena K. ; McCall, Anthony L. ; Charron, Maureen J. ; McEwen, Bruce S. / GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. In: Brain Research. 2002 ; Vol. 932, No. 1-2. pp. 129-134.
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