Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Peter G. Wells, Peter I. Mackenzie, Jayanta Roy Chowdhury, Chantal Guillemette, Philip A. Gregory, Yuji Ishii, Antony J. Hansen, Fay K. Kessler, Perry M. Kim, Namita Roy Chowdhury, Joseph K. Ritter

Research output: Contribution to journalArticle

191 Scopus citations

Abstract

This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalDrug Metabolism and Disposition
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., Hansen, A. J., Kessler, F. K., Kim, P. M., Chowdhury, N. R., & Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. Drug Metabolism and Disposition, 32(3), 281-290. https://doi.org/10.1124/dmd.32.3.281