Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Peter G. Wells, Peter I. Mackenzie, Jayanta Roy-Chowdhury, Chantal Guillemette, Philip A. Gregory, Yuji Ishii, Antony J. Hansen, Fay K. Kessler, Perry M. Kim, Namita Roy Chowdhury, Joseph K. Ritter

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalDrug Metabolism and Disposition
Volume32
Issue number3
DOIs
StatePublished - Mar 2004

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Glucuronosyltransferase
Health
Gene therapy
Neoplasm Genes
Xenobiotics
Polymorphism
Metabolism
Genetic Therapy
Toxicology
Genes
Pharmacology
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Wells, P. G., Mackenzie, P. I., Roy-Chowdhury, J., Guillemette, C., Gregory, P. A., Ishii, Y., ... Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. Drug Metabolism and Disposition, 32(3), 281-290. https://doi.org/10.1124/dmd.32.3.281

Glucuronidation and the UDP-glucuronosyltransferases in health and disease. / Wells, Peter G.; Mackenzie, Peter I.; Roy-Chowdhury, Jayanta; Guillemette, Chantal; Gregory, Philip A.; Ishii, Yuji; Hansen, Antony J.; Kessler, Fay K.; Kim, Perry M.; Chowdhury, Namita Roy; Ritter, Joseph K.

In: Drug Metabolism and Disposition, Vol. 32, No. 3, 03.2004, p. 281-290.

Research output: Contribution to journalArticle

Wells, PG, Mackenzie, PI, Roy-Chowdhury, J, Guillemette, C, Gregory, PA, Ishii, Y, Hansen, AJ, Kessler, FK, Kim, PM, Chowdhury, NR & Ritter, JK 2004, 'Glucuronidation and the UDP-glucuronosyltransferases in health and disease', Drug Metabolism and Disposition, vol. 32, no. 3, pp. 281-290. https://doi.org/10.1124/dmd.32.3.281
Wells, Peter G. ; Mackenzie, Peter I. ; Roy-Chowdhury, Jayanta ; Guillemette, Chantal ; Gregory, Philip A. ; Ishii, Yuji ; Hansen, Antony J. ; Kessler, Fay K. ; Kim, Perry M. ; Chowdhury, Namita Roy ; Ritter, Joseph K. / Glucuronidation and the UDP-glucuronosyltransferases in health and disease. In: Drug Metabolism and Disposition. 2004 ; Vol. 32, No. 3. pp. 281-290.
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