Glucose and diabetic vascular disease

Neil B. Ruderman, Joseph R. Williamson, Michael Brownlee

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

The central therapeutic problem in diabetes mellitus is prevention and treatment of the chronic vascular disease associated with this disorder. Prolonged exposure to hyperglycemia is the primary factor associated with the development of diabetes-specific microvascular disease, and the relationship between deranged glucose metabolism and arterial disease is complicated by many other factors that influence atherogenesis in nondiabetics. Until relatively recently, knowledge about diabetic vascular disease was limited mainly to clinical description. New information about abnormal vascular physiology, ultrastructure, biochemistry, cell biology, and molecular biology now makes it possible to understand in an integrated fashion the major specific mechanisms by which hyperglycemia damages diabetic vessels. Continued progress in this area will further optimize the development of safe and effective drugs for the treatment of diabetic vascular disease.

Original languageEnglish (US)
Pages (from-to)2905-2914
Number of pages10
JournalFASEB Journal
Volume6
Issue number11
StatePublished - Aug 1992

Fingerprint

Diabetic Angiopathies
vascular diseases
hyperglycemia
Glucose
Hyperglycemia
glucose
atherogenesis
Medical problems
diabetes mellitus
Vascular Diseases
blood vessels
cell biology
Biochemistry
biochemistry
molecular biology
drug therapy
Blood Vessels
Cell Biology
diabetes
Cytology

Keywords

  • Diacylglycerol synthesis
  • Glycation
  • Myoinositol transport
  • Na/K-ATPase
  • Pathogenesis
  • Pharmacology
  • Protein kinase C
  • Redox state
  • Sorbitol pathway

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992). Glucose and diabetic vascular disease. FASEB Journal, 6(11), 2905-2914.

Glucose and diabetic vascular disease. / Ruderman, Neil B.; Williamson, Joseph R.; Brownlee, Michael.

In: FASEB Journal, Vol. 6, No. 11, 08.1992, p. 2905-2914.

Research output: Contribution to journalArticle

Ruderman, NB, Williamson, JR & Brownlee, M 1992, 'Glucose and diabetic vascular disease', FASEB Journal, vol. 6, no. 11, pp. 2905-2914.
Ruderman NB, Williamson JR, Brownlee M. Glucose and diabetic vascular disease. FASEB Journal. 1992 Aug;6(11):2905-2914.
Ruderman, Neil B. ; Williamson, Joseph R. ; Brownlee, Michael. / Glucose and diabetic vascular disease. In: FASEB Journal. 1992 ; Vol. 6, No. 11. pp. 2905-2914.
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