Notch signaling regulates cell fate during the development of many tissues. A new Drosophila mutant, rumi, is defective in Notch signaling because it cannot add glucose to serine in epidermal growth factor repeats of Notch extracellular domain. This is the first biological role for glucose covalently attached to a cell surface signaling receptor.
ASJC Scopus subject areas
- Molecular Medicine