Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort

Elizabeth D. Kantor, Christina C. Newton, Edward L. Giovannucci, Marjorie L. McCullough, Peter T. Campbell, Eric J. Jacobs

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: Use of glucosamine supplements has been associated with reduced risk of colorectal cancer (CRC) in previous studies; however, information on this association remains limited. Methods: We examined the association between glucosamine use and CRC risk among 113,067 men and women in the Cancer Prevention Study II Nutrition Cohort. Glucosamine use was first reported in 2001 and updated every 2 years thereafter. Participants were followed from 2001 through June of 2011, during which time 1440 cases of CRC occurred. Results: As has been observed in prior studies, current use of glucosamine, modeled using a time-varying exposure, was associated with lower risk of CRC (HR 0.83; 95% CI 0.71–0.97) compared to never use. However, for reasons that are unclear, this reduction in risk was observed for shorter-duration use (HR 0.68; 95% CI 0.52–0.87 for current users with ≤ 2 years use) rather than longer-duration use (HR 0.90; 95% CI 0.72–1.13 for current users with 3 to OpenSPiltSPi 6 years of use; HR 0.99; 95% CI 0.76–1.29 for current users with ≥ 6 years of use). Conclusions: Further research is needed to better understand the association between glucosamine use and risk of CRC, and how this association may vary by duration of use.

Original languageEnglish (US)
Pages (from-to)389-397
Number of pages9
JournalCancer Causes and Control
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2018
Externally publishedYes

Keywords

  • Chemoprevention
  • Colorectal cancer
  • Dietary supplements
  • Epidemiology
  • Glucosamine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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