Glucocorticoids as mediators of developmental programming effects

Batbayar Khulan, Amanda J. Drake

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Epidemiological evidence suggests that exposure to an adverse environment in early life is associated with an increased risk of cardio-metabolic and behavioral disorders in adulthood, a phenomenon termed 'early life programming'. One major hypothesis for early life programming is fetal glucocorticoid overexposure. In animal studies, prenatal glucocorticoid excess as a consequence of maternal stress or through exogenous administration to the mother or fetus is associated with programming effects on cardiovascular and metabolic systems and on the brain. These effects can be transmitted to subsequent generations. Studies in humans provide some evidence that prenatal glucocorticoid exposure may exert similar programming effects on glucose/insulin homeostasis, blood pressure and neurodevelopment. The mechanisms by which glucocorticoids mediate these effects are unclear but may include a role for epigenetic modifications. This review discusses the evidence for glucocorticoid programming in animal models and in humans.

Original languageEnglish (US)
Pages (from-to)689-700
Number of pages12
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume26
Issue number5
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

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Keywords

  • 11β-hydroxysteroid dehydrogenase
  • epigenetic
  • glucocorticoids
  • hypothalamic-pituitary-adrenal axis
  • programming

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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