Globin messenger RNA in the thalassemia syndromes

B. G. Forget, D. Baltimore, E. J. Benz, D. Housman, P. Lebowitz, C. A. Marotta, R. P. McCaffrey, Arthur I. Skoultchi, P. S. Swerdlow, I. M. Verma, S. M. Weissman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The role of globin messenger RNA (mRNA) in the imbalance of globin synthesis in thalassemia has been established beyond doubt. The authors present the results of studies which indicate that in thalassemic reticulocytes there is not only deficiency of functional globin mRNA for the affected chain, but true quantitative deficiency of the affected mRNA. The demonstration of such a deficiency in thalassemic reticulocytes still leaves unresolved the precise nature of the molecular defect in thalassemia, and at least 2 general hypotheses can still be proposed: decreased transcription of mRNA from DNA or synthesis of a mRNA which is 'unstable' and rapidly degraded. Studies of mRNA in marrow cells and direct studies of DNA transcription should resolve the issue. In this work, patients from the Ferrara region of Italy were not studied. It is possible that the defect in Ferrara type β thalassemia is different from that found in patients of Southern Italian and Greek ancestry.

Original languageEnglish (US)
Pages (from-to)76-87
Number of pages12
JournalAnnals of the New York Academy of Sciences
VolumeVol.232
StatePublished - 1974
Externally publishedYes

Fingerprint

Thalassemia
Globins
Messenger RNA
Reticulocytes
Transcription
Defects
DNA
Italy
Syndrome
Demonstrations
Bone Marrow
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Forget, B. G., Baltimore, D., Benz, E. J., Housman, D., Lebowitz, P., Marotta, C. A., ... Weissman, S. M. (1974). Globin messenger RNA in the thalassemia syndromes. Annals of the New York Academy of Sciences, Vol.232, 76-87.

Globin messenger RNA in the thalassemia syndromes. / Forget, B. G.; Baltimore, D.; Benz, E. J.; Housman, D.; Lebowitz, P.; Marotta, C. A.; McCaffrey, R. P.; Skoultchi, Arthur I.; Swerdlow, P. S.; Verma, I. M.; Weissman, S. M.

In: Annals of the New York Academy of Sciences, Vol. Vol.232, 1974, p. 76-87.

Research output: Contribution to journalArticle

Forget, BG, Baltimore, D, Benz, EJ, Housman, D, Lebowitz, P, Marotta, CA, McCaffrey, RP, Skoultchi, AI, Swerdlow, PS, Verma, IM & Weissman, SM 1974, 'Globin messenger RNA in the thalassemia syndromes', Annals of the New York Academy of Sciences, vol. Vol.232, pp. 76-87.
Forget BG, Baltimore D, Benz EJ, Housman D, Lebowitz P, Marotta CA et al. Globin messenger RNA in the thalassemia syndromes. Annals of the New York Academy of Sciences. 1974;Vol.232:76-87.
Forget, B. G. ; Baltimore, D. ; Benz, E. J. ; Housman, D. ; Lebowitz, P. ; Marotta, C. A. ; McCaffrey, R. P. ; Skoultchi, Arthur I. ; Swerdlow, P. S. ; Verma, I. M. ; Weissman, S. M. / Globin messenger RNA in the thalassemia syndromes. In: Annals of the New York Academy of Sciences. 1974 ; Vol. Vol.232. pp. 76-87.
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AU - Forget, B. G.

AU - Baltimore, D.

AU - Benz, E. J.

AU - Housman, D.

AU - Lebowitz, P.

AU - Marotta, C. A.

AU - McCaffrey, R. P.

AU - Skoultchi, Arthur I.

AU - Swerdlow, P. S.

AU - Verma, I. M.

AU - Weissman, S. M.

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AB - The role of globin messenger RNA (mRNA) in the imbalance of globin synthesis in thalassemia has been established beyond doubt. The authors present the results of studies which indicate that in thalassemic reticulocytes there is not only deficiency of functional globin mRNA for the affected chain, but true quantitative deficiency of the affected mRNA. The demonstration of such a deficiency in thalassemic reticulocytes still leaves unresolved the precise nature of the molecular defect in thalassemia, and at least 2 general hypotheses can still be proposed: decreased transcription of mRNA from DNA or synthesis of a mRNA which is 'unstable' and rapidly degraded. Studies of mRNA in marrow cells and direct studies of DNA transcription should resolve the issue. In this work, patients from the Ferrara region of Italy were not studied. It is possible that the defect in Ferrara type β thalassemia is different from that found in patients of Southern Italian and Greek ancestry.

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