Global regulation of Hox gene expression in C. elegans by a SAM domain protein

Hong Zhang; Ricardo B.R. Azevedo; Robyn Lints; Christina Doyle; Yingqi Teng; Daniel Haber; Scott W. Emmons

doi:10.1016/S1534-5807(03)00136-9

Global regulation of Hox gene expression in C. elegans by a SAM domain protein

Hong Zhang, Ricardo B.R. Azevedo, Robyn Lints, Christina Doyle, Yingqi Teng, Daniel Haber, Scott W. Emmons

Genetics

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

Original language	English (US)
Pages (from-to)	903-915
Number of pages	13
Journal	Developmental cell
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S1534-5807(03)00136-9
State	Published - Jun 1 2003

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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title = "Global regulation of Hox gene expression in C. elegans by a SAM domain protein",

abstract = "Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.",

author = "Hong Zhang and Azevedo, {Ricardo B.R.} and Robyn Lints and Christina Doyle and Yingqi Teng and Daniel Haber and Emmons, {Scott W.}",

note = "Funding Information: We thank J. Ross and D. Zarkower for communicating their results prior to publication and for helpful discussions, D. Portman and R. Palmer for helpful comments on the manuscript, and S. van den Heuvel and A. Hart for providing laboratory space to finish some experiments. This work was supported by the NIH (2T32CA09216 to H.Z., CA58596 to D.A.H., and GM39353 to S.W.E.), NARSAD (Young Investigators Award to R.L.), and EMBO (Postdoctoral Fellowship to R.B.R.A.). S.W.E. is the Siegfried Ullmann Professor of Molecular Genetics.",

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AU - Zhang, Hong

AU - Azevedo, Ricardo B.R.

AU - Lints, Robyn

AU - Doyle, Christina

AU - Teng, Yingqi

AU - Haber, Daniel

AU - Emmons, Scott W.

N1 - Funding Information: We thank J. Ross and D. Zarkower for communicating their results prior to publication and for helpful discussions, D. Portman and R. Palmer for helpful comments on the manuscript, and S. van den Heuvel and A. Hart for providing laboratory space to finish some experiments. This work was supported by the NIH (2T32CA09216 to H.Z., CA58596 to D.A.H., and GM39353 to S.W.E.), NARSAD (Young Investigators Award to R.L.), and EMBO (Postdoctoral Fellowship to R.B.R.A.). S.W.E. is the Siegfried Ullmann Professor of Molecular Genetics.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

AB - Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

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Global regulation of Hox gene expression in C. elegans by a SAM domain protein

Abstract

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