Global regulation of Hox gene expression in C. elegans by a SAM domain protein

Hong Zhang, Ricardo B R Azevedo, Robyn Lints, Christina Doyle, Yingqi Teng, Daniel Haber, Scott W. Emmons

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

Original languageEnglish (US)
Pages (from-to)903-915
Number of pages13
JournalDevelopmental Cell
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Homeobox Genes
Gene Expression Regulation
Gene expression
Genes
Polycomb-Group Proteins
Proteins
Transcription Factors
Genome
Mutation
Sterile Alpha Motif

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Global regulation of Hox gene expression in C. elegans by a SAM domain protein. / Zhang, Hong; Azevedo, Ricardo B R; Lints, Robyn; Doyle, Christina; Teng, Yingqi; Haber, Daniel; Emmons, Scott W.

In: Developmental Cell, Vol. 4, No. 6, 01.06.2003, p. 903-915.

Research output: Contribution to journalArticle

Zhang, Hong ; Azevedo, Ricardo B R ; Lints, Robyn ; Doyle, Christina ; Teng, Yingqi ; Haber, Daniel ; Emmons, Scott W. / Global regulation of Hox gene expression in C. elegans by a SAM domain protein. In: Developmental Cell. 2003 ; Vol. 4, No. 6. pp. 903-915.
@article{55c4d98bfe034c4488c141f493e58a0d,
title = "Global regulation of Hox gene expression in C. elegans by a SAM domain protein",
abstract = "Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.",
author = "Hong Zhang and Azevedo, {Ricardo B R} and Robyn Lints and Christina Doyle and Yingqi Teng and Daniel Haber and Emmons, {Scott W.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S1534-5807(03)00136-9",
language = "English (US)",
volume = "4",
pages = "903--915",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Global regulation of Hox gene expression in C. elegans by a SAM domain protein

AU - Zhang, Hong

AU - Azevedo, Ricardo B R

AU - Lints, Robyn

AU - Doyle, Christina

AU - Teng, Yingqi

AU - Haber, Daniel

AU - Emmons, Scott W.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

AB - Polycomb group (PcG)-mediated repression of C. elegans Hox genes has not been demonstrated, and genes homologous to components of one of the PcG complexes (PRC1) have not been identified in the C. elegans genome. We find that a mechanism of general Hox gene repression exists in C. elegans, carried out in part by SOP-2, a protein related to, but not orthologous with, any PcG protein. sop-2 mutations lead to widespread ectopic expression of Hox genes and homeotic transformations. SOP-2 contains a SAM domain, a self-associating protein domain found in other repressors, including a core component of PRC1 and ETS transcription factors. Phylogenetic analysis indicates that this domain is more closely related to those of the ETS family than to those of PcG proteins. The results suggest that global repression of Hox genes has been taken over by a different branch of the SAM domain family during the evolution of nematodes.

UR - http://www.scopus.com/inward/record.url?scp=0038243171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038243171&partnerID=8YFLogxK

U2 - 10.1016/S1534-5807(03)00136-9

DO - 10.1016/S1534-5807(03)00136-9

M3 - Article

VL - 4

SP - 903

EP - 915

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 6

ER -