Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences

Mateja M. Jelen, Zigui Chen, Boštjan J. Kocjan, Lea Hošnjak, Felicity J. Burt, Paul K S Chan, Diego Chouhy, Catharina E. Combrinck, Christine Estrade, Alison Fiander, Suzanne M. Garland, Adriana A. Giri, Joaquín Víctor González, Arndt Gröning, Sam Hibbitts, Tommy N M Luk, Karina Marinic, Toshihiko Matsukura, Anna Neumann, Anja OštrbenkMaria Alejandra Picconi, Martin Sagadin, Roland Sahli, Riaz Y. Seedat, Katja Seme, Alberto Severini, Jessica L. Sinchi, Jana Smahelova, Sepehr N. Tabrizi, Ruth Tachezy, Sarah Tohme Faybush, Virgilijus Uloza, Ingrida Uloziene, Yong Wee Wong, Snježana Židovec Lepej, Robert D. Burk, Mario Poljak

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B.

Original languageEnglish (US)
Pages (from-to)5503-5513
Number of pages11
JournalJournal of Virology
Volume90
Issue number11
DOIs
StatePublished - Jun 1 2016

Fingerprint

Human papillomavirus 6
Human papillomavirus 11
Genome
genomics
genome
varespladib methyl
single nucleotide polymorphism
Single Nucleotide Polymorphism
Papillomavirus Vaccines
warts
Warts
papilloma
Nucleic Acid Regulatory Sequences
etiological agents
Nucleic Acid Databases
Papilloma
Open Reading Frames
Cluster Analysis
open reading frames
vaccines

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Jelen, M. M., Chen, Z., Kocjan, B. J., Hošnjak, L., Burt, F. J., Chan, P. K. S., ... Poljak, M. (2016). Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences. Journal of Virology, 90(11), 5503-5513. https://doi.org/10.1128/JVI.03149-15

Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences. / Jelen, Mateja M.; Chen, Zigui; Kocjan, Boštjan J.; Hošnjak, Lea; Burt, Felicity J.; Chan, Paul K S; Chouhy, Diego; Combrinck, Catharina E.; Estrade, Christine; Fiander, Alison; Garland, Suzanne M.; Giri, Adriana A.; González, Joaquín Víctor; Gröning, Arndt; Hibbitts, Sam; Luk, Tommy N M; Marinic, Karina; Matsukura, Toshihiko; Neumann, Anna; Oštrbenk, Anja; Picconi, Maria Alejandra; Sagadin, Martin; Sahli, Roland; Seedat, Riaz Y.; Seme, Katja; Severini, Alberto; Sinchi, Jessica L.; Smahelova, Jana; Tabrizi, Sepehr N.; Tachezy, Ruth; Faybush, Sarah Tohme; Uloza, Virgilijus; Uloziene, Ingrida; Wong, Yong Wee; Lepej, Snježana Židovec; Burk, Robert D.; Poljak, Mario.

In: Journal of Virology, Vol. 90, No. 11, 01.06.2016, p. 5503-5513.

Research output: Contribution to journalArticle

Jelen, MM, Chen, Z, Kocjan, BJ, Hošnjak, L, Burt, FJ, Chan, PKS, Chouhy, D, Combrinck, CE, Estrade, C, Fiander, A, Garland, SM, Giri, AA, González, JV, Gröning, A, Hibbitts, S, Luk, TNM, Marinic, K, Matsukura, T, Neumann, A, Oštrbenk, A, Picconi, MA, Sagadin, M, Sahli, R, Seedat, RY, Seme, K, Severini, A, Sinchi, JL, Smahelova, J, Tabrizi, SN, Tachezy, R, Faybush, ST, Uloza, V, Uloziene, I, Wong, YW, Lepej, SŽ, Burk, RD & Poljak, M 2016, 'Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences', Journal of Virology, vol. 90, no. 11, pp. 5503-5513. https://doi.org/10.1128/JVI.03149-15
Jelen, Mateja M. ; Chen, Zigui ; Kocjan, Boštjan J. ; Hošnjak, Lea ; Burt, Felicity J. ; Chan, Paul K S ; Chouhy, Diego ; Combrinck, Catharina E. ; Estrade, Christine ; Fiander, Alison ; Garland, Suzanne M. ; Giri, Adriana A. ; González, Joaquín Víctor ; Gröning, Arndt ; Hibbitts, Sam ; Luk, Tommy N M ; Marinic, Karina ; Matsukura, Toshihiko ; Neumann, Anna ; Oštrbenk, Anja ; Picconi, Maria Alejandra ; Sagadin, Martin ; Sahli, Roland ; Seedat, Riaz Y. ; Seme, Katja ; Severini, Alberto ; Sinchi, Jessica L. ; Smahelova, Jana ; Tabrizi, Sepehr N. ; Tachezy, Ruth ; Faybush, Sarah Tohme ; Uloza, Virgilijus ; Uloziene, Ingrida ; Wong, Yong Wee ; Lepej, Snježana Židovec ; Burk, Robert D. ; Poljak, Mario. / Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences. In: Journal of Virology. 2016 ; Vol. 90, No. 11. pp. 5503-5513.
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AU - Burt, Felicity J.

AU - Chan, Paul K S

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AU - Picconi, Maria Alejandra

AU - Sagadin, Martin

AU - Sahli, Roland

AU - Seedat, Riaz Y.

AU - Seme, Katja

AU - Severini, Alberto

AU - Sinchi, Jessica L.

AU - Smahelova, Jana

AU - Tabrizi, Sepehr N.

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AU - Faybush, Sarah Tohme

AU - Uloza, Virgilijus

AU - Uloziene, Ingrida

AU - Wong, Yong Wee

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