TY - JOUR
T1 - Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences
AU - Jelen, Mateja M.
AU - Chen, Zigui
AU - Kocjan, Boštjan J.
AU - Hošnjak, Lea
AU - Burt, Felicity J.
AU - Chan, Paul K.S.
AU - Chouhy, Diego
AU - Combrinck, Catharina E.
AU - Estrade, Christine
AU - Fiander, Alison
AU - Garland, Suzanne M.
AU - Giri, Adriana A.
AU - González, Joaquín Víctor
AU - Gröning, Arndt
AU - Hibbitts, Sam
AU - Luk, Tommy N.M.
AU - Marinic, Karina
AU - Matsukura, Toshihiko
AU - Neumann, Anna
AU - Oštrbenk, Anja
AU - Picconi, Maria Alejandra
AU - Sagadin, Martin
AU - Sahli, Roland
AU - Seedat, Riaz Y.
AU - Seme, Katja
AU - Severini, Alberto
AU - Sinchi, Jessica L.
AU - Smahelova, Jana
AU - Tabrizi, Sepehr N.
AU - Tachezy, Ruth
AU - Faybush, Sarah Tohme
AU - Uloza, Virgilijus
AU - Uloziene, Ingrida
AU - Wong, Yong Wee
AU - Lepej, Snježana Židovec
AU - Burk, Robert D.
AU - Poljak, Mario
N1 - Funding Information:
This work, including the efforts of Mateja M. Jelen, was funded by Slovenian Research Agency (1000-10-310163). This work, including the efforts of Lea Hošnjak, Anja Oštrbenk, and Mario Poljak, was funded by European Commission FP7 Program (603019). This work, including the efforts of Mario Poljak, was funded by Merck Sharp and Dohme (research grant). This work, including the efforts of Robert D. Burk, was funded by HHS | NIH | National Cancer Institute (NCI) (CA78527 and P30CA013330). This work, including the efforts of Robert D. Burk, was funded by HHS | National Institutes of Health (NIH) (AI-51519). This work, including the efforts of Mateja M. Jelen, was funded by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (research grant 2014).
Publisher Copyright:
© 2016, American Society for Microbiology.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B.
AB - Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B.
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U2 - 10.1128/JVI.03149-15
DO - 10.1128/JVI.03149-15
M3 - Article
C2 - 27030261
AN - SCOPUS:84971440681
SN - 0022-538X
VL - 90
SP - 5503
EP - 5513
JO - Journal of Virology
JF - Journal of Virology
IS - 11
ER -
