Glial cells in neurotoxicity development

Michael Aschner, J. W. Allen, H. K. Kimelberg, Richard M. LoPachin, W. J. Streit

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Neuroglial cells of the central nervous system include the astrocytes, oligodendrocytes, and microglia. Their counterparts in the peripheral nervous system are the Schwann cells. The term neuroglia comes from an erroneous concept originally coined by Virchow (1850), in which he envisioned the neurons to be embedded in a layer of connective tissue. The term, or its shortened form-glia, has persisted as the preferred generic term of these cells. A reciprocal relationship exists between neurons and glia, and this association is vital for mutual differentiation, development, and functioning of these cell types. Therefore, perturbations in glial cell function, as well as glial metabolism of chemicals to active intermediates, can lead to neuronal dysfunction. The purpose of this review is to explore neurological sites of neurotoxicant actions, discuss potential mechanisms of glial- induced or glial-mediated central nervous system and peripheral nervous system damage, and review the role of glial cells in neurotoxicity development.

Original languageEnglish (US)
Pages (from-to)151-173
Number of pages23
JournalAnnual Review of Pharmacology and Toxicology
Volume39
DOIs
StatePublished - 1999

Fingerprint

Neuroglia
Neurology
Peripheral Nervous System
Neurons
Central Nervous System
Schwann Cells
Oligodendroglia
Microglia
Metabolism
Astrocytes
Connective Tissue
Action Potentials
Cells
Tissue

Keywords

  • Astrocytes
  • Microglia
  • Neuroglia
  • Oligodendrocytes
  • Schwann cells

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Glial cells in neurotoxicity development. / Aschner, Michael; Allen, J. W.; Kimelberg, H. K.; LoPachin, Richard M.; Streit, W. J.

In: Annual Review of Pharmacology and Toxicology, Vol. 39, 1999, p. 151-173.

Research output: Contribution to journalArticle

Aschner, Michael ; Allen, J. W. ; Kimelberg, H. K. ; LoPachin, Richard M. ; Streit, W. J. / Glial cells in neurotoxicity development. In: Annual Review of Pharmacology and Toxicology. 1999 ; Vol. 39. pp. 151-173.
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