Glia and methylmercury neurotoxicity

Mingwei Ni, Xin Li, João B T Rocha, Marcelo Farina, Michael Aschner

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.

Original languageEnglish (US)
Pages (from-to)1091-1101
Number of pages11
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume75
Issue number16-17
DOIs
Publication statusPublished - Aug 15 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

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