Glare Disability in Nephropathic Cystinosis

Barrett Katz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Cystinosis is a rare metabolic disorder in which nonprotein cystine accumulates within lysosomes due to a defect in lysosomal cystine transport. Although cystine accumulates within most ocular tissues, patients with cystinosis generally complain only of photophobia and glare. We measured glare sensitivity in 12 patients with infantile cystinosis and compared their results with an age-matched control population. Ten of the 12 patients with cystinosis had demonstrable glare disability when compared with the control group. Glare disability scores in the patients with cystinosis ranged from 5% to 50%. Dazzle glare resulting from the accumulation of cystine crystals in ocular tissue may account for glare disability seen in these patients and contribute to their complaints of photophobia.

Original languageEnglish (US)
Pages (from-to)1670-1671
Number of pages2
JournalArchives of Ophthalmology
Volume105
Issue number12
DOIs
StatePublished - Dec 1987

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ASJC Scopus subject areas

  • Ophthalmology

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