Glanzmann's thrombasthenia in pregnancy: A case and review of the literature

David M. Sherer, Roy Lerner

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Glanzmann's thrombasthenia is a rare autosomal recessive bleeding disorder resulting from a deficiency of glycoprotein IIb-IIIa complex in platelets. The deficient complex normally mediates platelet aggregation by binding adhesive proteins, which form bridges between activated cells. Despite normal platelet counts, morphology, prothrombin, and activated thromboplastin times, Glanzmann's thrombasthenia is characterized by a prolonged bleeding time and a severe hemorrhagic mucocutaneous diathesis. Pregnancy and delivery are rare in these patients and have been associated with a high risk of severe hemorrhage. We present an unusual case in which a primigravida patient with Glanzmann's thrombasthenia underwent an uneventful pregnancy and spontaneous vaginal delivery, following intrapartum intravenous administration of single-donor platelets. Subsequent late postpartum hemorrhage required intravenous transfusion of an additional unit of single- donor platelets. In addition, we review the literature pertaining to pregnancy and Glanzmann's thrombasthenia with an emphasis on intrapartum prophylactic management.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalAmerican Journal of Perinatology
Volume16
Issue number6
DOIs
Publication statusPublished - Jan 1 1999

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Keywords

  • Glanzmann's thrombasthenia
  • Intrapartum hemorrhage
  • Platelet transfusion
  • Postpartum hemorrhage
  • Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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