Abstract
Older adults represent the fastest growing demographic in both developing and developed countries. Understanding pharmacokinetic and pharmacodynamic principles relevant to psychopharmacology in geriatric patients is increasingly important to optimize psychiatric treatment. This review discusses the four pharmacokinetic processes (absorption, distribution, metabolism, and excretion) with regard to age-related changes. These include a generally slower rate of absorption, increases in the ratio of adipose to lean body mass and volume of distribution of medications, reductions in phase I metabolism, and decreases in renal function. In addition, this review discusses pharmacodynamic factors relevant to pharmacotherapy in older age, such as changes in receptor density and homeostatic and regulatory mechanisms. Geriatric psychopharmacology will benefit from an expanding evidence base as research on pharmacokinetics and pharmacodynamics increasingly includes older individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 336-341 |
| Number of pages | 6 |
| Journal | Psychiatric Annals |
| Volume | 45 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Geriatric psychopharmacology : Pharmacokinetic and pharmacodynamic considerations. / Carlo, Andrew D.; Alpert, Jonathan E.
In: Psychiatric Annals, Vol. 45, No. 7, 01.07.2015, p. 336-341.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Geriatric psychopharmacology
T2 - Pharmacokinetic and pharmacodynamic considerations
AU - Carlo, Andrew D.
AU - Alpert, Jonathan E.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Older adults represent the fastest growing demographic in both developing and developed countries. Understanding pharmacokinetic and pharmacodynamic principles relevant to psychopharmacology in geriatric patients is increasingly important to optimize psychiatric treatment. This review discusses the four pharmacokinetic processes (absorption, distribution, metabolism, and excretion) with regard to age-related changes. These include a generally slower rate of absorption, increases in the ratio of adipose to lean body mass and volume of distribution of medications, reductions in phase I metabolism, and decreases in renal function. In addition, this review discusses pharmacodynamic factors relevant to pharmacotherapy in older age, such as changes in receptor density and homeostatic and regulatory mechanisms. Geriatric psychopharmacology will benefit from an expanding evidence base as research on pharmacokinetics and pharmacodynamics increasingly includes older individuals.
AB - Older adults represent the fastest growing demographic in both developing and developed countries. Understanding pharmacokinetic and pharmacodynamic principles relevant to psychopharmacology in geriatric patients is increasingly important to optimize psychiatric treatment. This review discusses the four pharmacokinetic processes (absorption, distribution, metabolism, and excretion) with regard to age-related changes. These include a generally slower rate of absorption, increases in the ratio of adipose to lean body mass and volume of distribution of medications, reductions in phase I metabolism, and decreases in renal function. In addition, this review discusses pharmacodynamic factors relevant to pharmacotherapy in older age, such as changes in receptor density and homeostatic and regulatory mechanisms. Geriatric psychopharmacology will benefit from an expanding evidence base as research on pharmacokinetics and pharmacodynamics increasingly includes older individuals.
UR - http://www.scopus.com/inward/record.url?scp=84946829331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946829331&partnerID=8YFLogxK
U2 - 10.3928/00485713-20150626-04
DO - 10.3928/00485713-20150626-04
M3 - Review article
VL - 45
SP - 336
EP - 341
JO - Psychiatric Annals
JF - Psychiatric Annals
SN - 0048-5713
IS - 7
ER -