TY - JOUR
T1 - Genotypic distribution of hepatitis B virus (HBV) among acute cases of HBV infection, selected United States Counties, 1999-2005
AU - Teshale, Eyasu H.
AU - Ramachandran, Sumathi
AU - Xia, Guo Liang
AU - Roberts, Henry
AU - Groeger, Justina
AU - Barry, Vaughn
AU - Hu, Dale J.
AU - Holmberg, Scott D.
AU - Holtzman, Deborah
AU - Ward, John W.
AU - Teo, Chong Gee
AU - Khudyakov, Yuri
PY - 2011/10/15
Y1 - 2011/10/15
N2 - Background. Knowledge of the genotypic distribution of hepatitis B virus (HBV) facilitates epidemiologic tracking and surveillance of HBV infection as well as prediction of its disease burden. In the United States, HBV genotyping studies have been conducted for chronic but not acute hepatitis B. Methods. Serum samples were collected from patients with acute hepatitis B cases reported from the 6 counties that participated in the Sentinel Counties Study of Acute Viral Hepatitis from 1999 through 2005. Polymerase chain reaction followed by nucleotide sequencing of a 435-base pair segment of the HBV S gene was performed, and the sequences were phylogenetically analyzed. Results. Of 614 patients identified with available serum samples, 75% were infected with genotype A HBV and 18% were infected with genotype D HBV. Thirty-two percent of genotype A sequences constituted a single subgenotype A2 cluster. The odds of infection with genotype A (vs with genotype D) were 5 times greater among black individuals than among Hispanic individuals (odds ratio [OR], 5; 95% confidence interval [CI], 2.3-10.7). The odds of infection with genotype A were 49, 8, and 4 times greater among patients from Jefferson County (Alabama), Pinellas County (Florida), and San Francisco (California), respectively, than among those living in Denver County (Colorado). Genotype A was less common among recent injection drug users than it was among non-injection drug users (OR, 0.2; 95% CI, 0.1-0.4). Conclusions. HBV genotype distribution was significantly associated with ethnicity, place of residence, and risk behavior.
AB - Background. Knowledge of the genotypic distribution of hepatitis B virus (HBV) facilitates epidemiologic tracking and surveillance of HBV infection as well as prediction of its disease burden. In the United States, HBV genotyping studies have been conducted for chronic but not acute hepatitis B. Methods. Serum samples were collected from patients with acute hepatitis B cases reported from the 6 counties that participated in the Sentinel Counties Study of Acute Viral Hepatitis from 1999 through 2005. Polymerase chain reaction followed by nucleotide sequencing of a 435-base pair segment of the HBV S gene was performed, and the sequences were phylogenetically analyzed. Results. Of 614 patients identified with available serum samples, 75% were infected with genotype A HBV and 18% were infected with genotype D HBV. Thirty-two percent of genotype A sequences constituted a single subgenotype A2 cluster. The odds of infection with genotype A (vs with genotype D) were 5 times greater among black individuals than among Hispanic individuals (odds ratio [OR], 5; 95% confidence interval [CI], 2.3-10.7). The odds of infection with genotype A were 49, 8, and 4 times greater among patients from Jefferson County (Alabama), Pinellas County (Florida), and San Francisco (California), respectively, than among those living in Denver County (Colorado). Genotype A was less common among recent injection drug users than it was among non-injection drug users (OR, 0.2; 95% CI, 0.1-0.4). Conclusions. HBV genotype distribution was significantly associated with ethnicity, place of residence, and risk behavior.
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U2 - 10.1093/cid/cir495
DO - 10.1093/cid/cir495
M3 - Article
C2 - 21860013
AN - SCOPUS:80052897318
SN - 1058-4838
VL - 53
SP - 751
EP - 756
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 8
ER -