@article{f7fde184a5f64c2aaefa704a916aa9ce,
title = "Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies",
abstract = "The resurgence of yellow fever in South America has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. We show that antiviral potency of the polyclonal antibody response in vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to amino acid changes at two sites in central domain II of the glycoprotein E, including multiple changes at the domain I–domain II hinge, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for updating vaccines.",
keywords = "17D, South America, antibody response, emerging virus, flavivirus, glycoprotein, immunological response, neutralizing antibodies, vaccine, yellow fever virus",
author = "Denise Haslwanter and Gorka Lasso and Wec, {Anna Z.} and Furtado, {Nath{\'a}lia Dias} and Raphael, {Lidiane Menezes Souza} and Tse, {Alexandra L.} and Yan Sun and Stephanie Stransky and N{\'u}ria Pedre{\~n}o-Lopez and Correia, {Carolina Argondizo} and Bornholdt, {Zachary A.} and Mrunal Sakharkar and Avelino-Silva, {Vivian I.} and Moyer, {Crystal L.} and Watkins, {David I.} and Kallas, {Esper G.} and Simone Sidoli and Walker, {Laura M.} and Bonaldo, {Myrna C.} and Kartik Chandran",
note = "Funding Information: We thank I. Gutierrez, E. Valencia, and L. Polanco for laboratory management and technical support. We thank T.C. Pierson for his provision of the WNV-based RVP system. This work was funded by the U.S. National Institutes of Health grant R01AI132633 (to K.C.), “Preventing and Combating the Zika Virus” MCTIC/FNDCT-CNPq/MEC-CAPES/MS-Decit. (grant 440865/2016-6 ) (to M.C.B.) and Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (grant 312446/2018 ) (to M.C.B.). M.C.B. is a recipient of CNPq fellowship for Productivity in Technological Development and Innovative Extension (grant 309471/2016-8 ). Si.Si. and St.St. were supported by the Leukemia Research Foundation (Hollis Brownstein New Investigator Research Grant), AFAR (Sagol Network GenOmics award), Deerfield (Xseed award), and the NIH Office of the Director ( 1S10OD030286-01 ). Y.S. gratefully acknowledges the NIH grant R01GM129350-04 . C.A.C. is a recipient of the PhD scholarship provided by the Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior Brasil (CAPES). A.L.T. was partially supported by NIH training grant 2T32GM007288-45 (Medical Scientist Training Program) at Albert Einstein College of Medicine. Funding Information: We thank I. Gutierrez, E. Valencia, and L. Polanco for laboratory management and technical support. We thank T.C. Pierson for his provision of the WNV-based RVP system. This work was funded by the U.S. National Institutes of Health grant R01AI132633 (to K.C.), ?Preventing and Combating the Zika Virus? MCTIC/FNDCT-CNPq/MEC-CAPES/MS-Decit. (grant 440865/2016-6) (to M.C.B.) and Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (grant 312446/2018) (to M.C.B.). M.C.B. is a recipient of CNPq fellowship for Productivity in Technological Development and Innovative Extension (grant 309471/2016-8). Si.Si. and St.St. were supported by the Leukemia Research Foundation (Hollis Brownstein New Investigator Research Grant), AFAR (Sagol Network GenOmics award), Deerfield (Xseed award), and the NIH Office of the Director (1S10OD030286-01). Y.S. gratefully acknowledges the NIH grant R01GM129350-04. C.A.C. is a recipient of the PhD scholarship provided by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior Brasil (CAPES). A.L.T. was partially supported by NIH training grant 2T32GM007288-45 (Medical Scientist Training Program) at Albert Einstein College of Medicine. Conceptualization, D.H. G.L. A.Z.W. L.M.W. M.C.B. and K.C.; investigation, D.H. G.L. A.Z.W. N.D.F. L.M.S.R. Y.S. St.St. N.P.-L. A.L.T.; formal analysis, D.H. and K.C.; resources, C.A.C. C.L.M. M.S. V.I.A.-S. Z.A.B. E.G.K. L.M.W. M.C.B. and K.C.; data curation, D.H. G.L. A.Z.W. and M.S.; writing?original draft, D.H. G.L. A.Z.W. and K.C.; writing?review & editing: all authors; visualization, D.H. G.L. A.Z.W. and K.C.; supervision, Z.A.B. D.I.W. E.G.K. Si.Si. L.M.W. M.C.B. and K.C.; project administration, D.H. and K.C.; funding acquisition, E.G.K. M.C.B. and K.C. K.C. is a member of the scientific advisory boards of Integrum Scientific, Biovaxys Technology, and the Pandemic Security Initiative of Celdara Medical. A.Z.W. M.S. and L.M.W. are/were employees of Adimab, and may hold shares in Adimab. L.M.W. is an employee of Adagio Therapeutics, and holds shares in Adagio Therapeutics. C.L.M. and Z.A.B. are employees of Mapp Biopharmaceutical. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2022",
month = feb,
day = "9",
doi = "10.1016/j.chom.2021.12.009",
language = "English (US)",
volume = "30",
pages = "248--259.e6",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "2",
}
