Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference

J. Maximilian Fels, Saad Khan, Ryan Forster, Karin A. Skalina, Surksha Sirichand, Amy S. Fox, Aviv Bergman, William B. Mitchell, Lucia R. Wolgast, Wendy Szymczak, Robert H. Bortz, M. Eugenia Dieterle, Catalina Florez, Denise Haslwanter, Rohit K. Jangra, Ethan Laudermilch, Ariel S. Wirchnianski, Jason Barnhill, David L. Goldman, Hnin KhineD. Yitzchak Goldstein, Johanna P. Daily, Kartik Chandran, Libusha Kelly

Research output: Contribution to journalArticlepeer-review

Abstract

The Bronx was an early epicenter of the COVID-19 pandemic in the United States. We conducted temporal genomic surveillance of 104 SARS-CoV-2 genomes across the Bronx from March to October 2020. Although the local structure of SARS-CoV-2 lineages mirrored those of New York City and New York State, temporal sampling revealed a dynamic and changing landscape of SARS-CoV-2 genomic diversity. Mapping the trajectories of mutations, we found that although some became "endemic"to the Bronx, other, novel mutations rose in prevalence in the late summer/early fall. Geographically resolved genomes enabled us to distinguish between cases of reinfection and persistent infection in two pediatric patients. We propose that limited, targeted, temporal genomic surveillance has clinical and epidemiological utility in managing the ongoing COVID pandemic.

Original languageEnglish (US)
Article numbera006211
JournalCold Spring Harbor Molecular Case Studies
Volume8
Issue number5
DOIs
StatePublished - Aug 2022

ASJC Scopus subject areas

  • General Medicine

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