Genomic imprinting and chromatin insulation in Beckwith-Wiedemann syndrome

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Genes are recognized as undergoing genomic imprinting when they are capable of being expressed only from the paternal or only from the maternal chromosome. The process can occur coordinately within large physical domains in mammalian chromosomes. One interesting facet of the study of genomic imprinting is that it offers insight into the regulation of large chromosomal regions. Understanding this regulation involves elucidating the cis-acting regulations of gene expression and defining the elements that maintain chromatin insulation, both required for understanding more practically applicable areas of biological research, such as efficient transgene production. This review is focused on the regulation of the imprinted domain of human chromosome 11p15.5, responsible for Beckwith-Wiedemann syndrome (BWS). Recent findings indicate that the maintenance of imprinting within this domain is critically dependent on the stable maintenance of chromatin insulation.

Original languageEnglish (US)
Pages (from-to)159-173
Number of pages15
JournalApplied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Volume11
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Beckwith-Wiedemann Syndrome
Genomic Imprinting
Chromosomes
Chromatin
Insulation
Mammalian Chromosomes
Maintenance
Gene Expression Regulation
Human Chromosomes
Transgenes
Mothers
Gene expression
Genes
Research

Keywords

  • Beckwith-Weidemann syndrome
  • Chromatin
  • Chromosome abnormalities
  • CpG islands
  • Genomic imprinting
  • Heterochromatin
  • Insulin-like growth factor II

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

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AU - Greally, John M.

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AB - Genes are recognized as undergoing genomic imprinting when they are capable of being expressed only from the paternal or only from the maternal chromosome. The process can occur coordinately within large physical domains in mammalian chromosomes. One interesting facet of the study of genomic imprinting is that it offers insight into the regulation of large chromosomal regions. Understanding this regulation involves elucidating the cis-acting regulations of gene expression and defining the elements that maintain chromatin insulation, both required for understanding more practically applicable areas of biological research, such as efficient transgene production. This review is focused on the regulation of the imprinted domain of human chromosome 11p15.5, responsible for Beckwith-Wiedemann syndrome (BWS). Recent findings indicate that the maintenance of imprinting within this domain is critically dependent on the stable maintenance of chromatin insulation.

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KW - Heterochromatin

KW - Insulin-like growth factor II

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