Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication

Bridgett M. Vonholdt, John P. Pollinger, Kirk E. Lohmueller, Eunjung Han, Heidi G. Parker, Pascale Quignon, Jeremiah D. Degenhardt, Adam R. Boyko, Dent A. Earl, Adam Auton, Andy Reynolds, Kasia Bryc, Abra Brisbin, James C. Knowles, Dana S. Mosher, Tyrone C. Spady, Abdel Elkahloun, Eli Geffen, Malgorzata Pilot, Wlodzimierz Jedrzejewski & 16 others Claudia Greco, Ettore Randi, Danika Bannasch, Alan Wilton, Jeremy Shearman, Marco Musiani, Michelle Cargill, Paul G. Jones, Zuwei Qian, Wei Huang, Zhao Li Ding, Ya Ping Zhang, Carlos D. Bustamante, Elaine A. Ostrander, John Novembre, Robert K. Wayne

Research output: Contribution to journalArticle

412 Citations (Scopus)

Abstract

Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dog diversification better, we conducted an extensive genome-wide survey of more than 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf. Here we show that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data. Furthermore, we find a surprising correspondence between genetic and phenotypic/functional breed groupings but there are exceptions that suggest phenotypic diversification depended in part on the repeated crossing of individuals with novel phenotypes. Our results show that Middle Eastern wolves were a critical source of genome diversity, although interbreeding with local wolf populations clearly occurred elsewhere in the early history of specific lineages. More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity.

Original languageEnglish (US)
Pages (from-to)898-902
Number of pages5
JournalNature
Volume464
Issue number7290
DOIs
StatePublished - Apr 8 2010
Externally publishedYes

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Haplotypes
Single Nucleotide Polymorphism
History
Genome
Dogs
Genetic Phenomena
Middle East
Far East
Mitochondrial DNA
Domestication
Technology
Phenotype
Population

ASJC Scopus subject areas

  • General

Cite this

Vonholdt, B. M., Pollinger, J. P., Lohmueller, K. E., Han, E., Parker, H. G., Quignon, P., ... Wayne, R. K. (2010). Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature, 464(7290), 898-902. https://doi.org/10.1038/nature08837

Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. / Vonholdt, Bridgett M.; Pollinger, John P.; Lohmueller, Kirk E.; Han, Eunjung; Parker, Heidi G.; Quignon, Pascale; Degenhardt, Jeremiah D.; Boyko, Adam R.; Earl, Dent A.; Auton, Adam; Reynolds, Andy; Bryc, Kasia; Brisbin, Abra; Knowles, James C.; Mosher, Dana S.; Spady, Tyrone C.; Elkahloun, Abdel; Geffen, Eli; Pilot, Malgorzata; Jedrzejewski, Wlodzimierz; Greco, Claudia; Randi, Ettore; Bannasch, Danika; Wilton, Alan; Shearman, Jeremy; Musiani, Marco; Cargill, Michelle; Jones, Paul G.; Qian, Zuwei; Huang, Wei; Ding, Zhao Li; Zhang, Ya Ping; Bustamante, Carlos D.; Ostrander, Elaine A.; Novembre, John; Wayne, Robert K.

In: Nature, Vol. 464, No. 7290, 08.04.2010, p. 898-902.

Research output: Contribution to journalArticle

Vonholdt, BM, Pollinger, JP, Lohmueller, KE, Han, E, Parker, HG, Quignon, P, Degenhardt, JD, Boyko, AR, Earl, DA, Auton, A, Reynolds, A, Bryc, K, Brisbin, A, Knowles, JC, Mosher, DS, Spady, TC, Elkahloun, A, Geffen, E, Pilot, M, Jedrzejewski, W, Greco, C, Randi, E, Bannasch, D, Wilton, A, Shearman, J, Musiani, M, Cargill, M, Jones, PG, Qian, Z, Huang, W, Ding, ZL, Zhang, YP, Bustamante, CD, Ostrander, EA, Novembre, J & Wayne, RK 2010, 'Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication', Nature, vol. 464, no. 7290, pp. 898-902. https://doi.org/10.1038/nature08837
Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P et al. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature. 2010 Apr 8;464(7290):898-902. https://doi.org/10.1038/nature08837
Vonholdt, Bridgett M. ; Pollinger, John P. ; Lohmueller, Kirk E. ; Han, Eunjung ; Parker, Heidi G. ; Quignon, Pascale ; Degenhardt, Jeremiah D. ; Boyko, Adam R. ; Earl, Dent A. ; Auton, Adam ; Reynolds, Andy ; Bryc, Kasia ; Brisbin, Abra ; Knowles, James C. ; Mosher, Dana S. ; Spady, Tyrone C. ; Elkahloun, Abdel ; Geffen, Eli ; Pilot, Malgorzata ; Jedrzejewski, Wlodzimierz ; Greco, Claudia ; Randi, Ettore ; Bannasch, Danika ; Wilton, Alan ; Shearman, Jeremy ; Musiani, Marco ; Cargill, Michelle ; Jones, Paul G. ; Qian, Zuwei ; Huang, Wei ; Ding, Zhao Li ; Zhang, Ya Ping ; Bustamante, Carlos D. ; Ostrander, Elaine A. ; Novembre, John ; Wayne, Robert K. / Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. In: Nature. 2010 ; Vol. 464, No. 7290. pp. 898-902.
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