Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

Anne E. Justice; Kristin Young; Stephanie M. Gogarten; Tamar Sofer; Misa Graff; Shelly Ann M. Love; Yujie Wang; Yann C. Klimentidis; Miguel Cruz; Xiuqing Guo; Fernando Hartwig; Lauren Petty; Jie Yao; Matthew A. Allison; Jennifer E. Below; Thomas A. Buchanan; Yii Der Ida Chen; Mark O. Goodarzi; Craig Hanis; Heather M. Highland; Willa A. Hsueh; Eli Ipp; Esteban Parra; Walter Palmas; Leslie J. Raffel; Jerome I. Rotter; Jingyi Tan; Kent D. Taylor; Adan Valladares; Anny H. Xiang; Lisa Sánchez-Johnsen; Carmen R. Isasi; Kari E. North

doi:10.1093/hmg/ddab166

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

Anne E. Justice, Kristin Young, Stephanie M. Gogarten, Tamar Sofer, Misa Graff, Shelly Ann M. Love, Yujie Wang, Yann C. Klimentidis, Miguel Cruz, Xiuqing Guo, Fernando Hartwig, Lauren Petty, Jie Yao, Matthew A. Allison, Jennifer E. Below, Thomas A. Buchanan, Yii Der Ida Chen, Mark O. Goodarzi, Craig Hanis, Heather M. HighlandWilla A. Hsueh, Eli Ipp, Esteban Parra, Walter Palmas, Leslie J. Raffel, Jerome I. Rotter, Jingyi Tan, Kent D. Taylor, Adan Valladares, Anny H. Xiang, Lisa Sánchez-Johnsen, Carmen R. Isasi, Kari E. North

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.

Original language	English (US)
Pages (from-to)	2190-2204
Number of pages	15
Journal	Human molecular genetics
Volume	30
Issue number	22
DOIs	https://doi.org/10.1093/hmg/ddab166
State	Published - Nov 15 2021

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/hmg/ddab166

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Justice, A. E., Young, K., Gogarten, S. M., Sofer, T., Graff, M., Love, S. A. M., Wang, Y., Klimentidis, Y. C., Cruz, M., Guo, X., Hartwig, F., Petty, L., Yao, J., Allison, M. A., Below, J. E., Buchanan, T. A., Chen, Y. D. I., Goodarzi, M. O., Hanis, C., ... North, K. E. (2021). Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Human molecular genetics, 30(22), 2190-2204. https://doi.org/10.1093/hmg/ddab166

Justice, AE, Young, K, Gogarten, SM, Sofer, T, Graff, M, Love, SAM, Wang, Y, Klimentidis, YC, Cruz, M, Guo, X, Hartwig, F, Petty, L, Yao, J, Allison, MA, Below, JE, Buchanan, TA, Chen, YDI, Goodarzi, MO, Hanis, C, Highland, HM, Hsueh, WA, Ipp, E, Parra, E, Palmas, W, Raffel, LJ, Rotter, JI, Tan, J, Taylor, KD, Valladares, A, Xiang, AH, Sánchez-Johnsen, L, Isasi, CR & North, KE 2021, 'Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL', Human molecular genetics, vol. 30, no. 22, pp. 2190-2204. https://doi.org/10.1093/hmg/ddab166

@article{f31ce286be984bbd9c103a5a2a69cbc0,

title = "Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL",

abstract = "Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.",

author = "Justice, {Anne E.} and Kristin Young and Gogarten, {Stephanie M.} and Tamar Sofer and Misa Graff and Love, {Shelly Ann M.} and Yujie Wang and Klimentidis, {Yann C.} and Miguel Cruz and Xiuqing Guo and Fernando Hartwig and Lauren Petty and Jie Yao and Allison, {Matthew A.} and Below, {Jennifer E.} and Buchanan, {Thomas A.} and Chen, {Yii Der Ida} and Goodarzi, {Mark O.} and Craig Hanis and Highland, {Heather M.} and Hsueh, {Willa A.} and Eli Ipp and Esteban Parra and Walter Palmas and Raffel, {Leslie J.} and Rotter, {Jerome I.} and Jingyi Tan and Taylor, {Kent D.} and Adan Valladares and Xiang, {Anny H.} and Lisa S{\'a}nchez-Johnsen and Isasi, {Carmen R.} and North, {Kari E.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press.",

year = "2021",

month = nov,

day = "15",

doi = "10.1093/hmg/ddab166",

language = "English (US)",

volume = "30",

pages = "2190--2204",

journal = "Human molecular genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "22",

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TY - JOUR

T1 - Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

AU - Justice, Anne E.

AU - Young, Kristin

AU - Gogarten, Stephanie M.

AU - Sofer, Tamar

AU - Graff, Misa

AU - Love, Shelly Ann M.

AU - Wang, Yujie

AU - Klimentidis, Yann C.

AU - Cruz, Miguel

AU - Guo, Xiuqing

AU - Hartwig, Fernando

AU - Petty, Lauren

AU - Yao, Jie

AU - Allison, Matthew A.

AU - Below, Jennifer E.

AU - Buchanan, Thomas A.

AU - Chen, Yii Der Ida

AU - Goodarzi, Mark O.

AU - Hanis, Craig

AU - Highland, Heather M.

AU - Hsueh, Willa A.

AU - Ipp, Eli

AU - Parra, Esteban

AU - Palmas, Walter

AU - Raffel, Leslie J.

AU - Rotter, Jerome I.

AU - Tan, Jingyi

AU - Taylor, Kent D.

AU - Valladares, Adan

AU - Xiang, Anny H.

AU - Sánchez-Johnsen, Lisa

AU - Isasi, Carmen R.

AU - North, Kari E.

PY - 2021/11/15

Y1 - 2021/11/15

N2 - Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.

AB - Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.

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DO - 10.1093/hmg/ddab166

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ER -

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

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