Genome and hormones: Gender differences in physiology invited review: Sex-based differences in gene expression

Research output: Contribution to journalReview article

19 Scopus citations


Certain diseases are more prevalent among women than men. The reasons for this increased prevalence are unknown, but there could be a genetic basis. Increased expression of X-linked genes in females, protective effects of Y-linked genes in males, or sex-limited gene expression that is developmentally or hormonally regulated could all account for these differences. Analysis of individuals with and without genetic sex reversal provides a means for distinguishing between genetic and hormonal causes. This can be complemented by genetic linkage and gene expression profiling to aid in the identification of candidate genes.

Original languageEnglish (US)
Pages (from-to)2384-2388
Number of pages5
JournalJournal of Applied Physiology
Issue number5
Publication statusPublished - Nov 10 2001
Externally publishedYes



  • Sex determination
  • Sex-limited gene expression
  • X-linked genes
  • Y-linked genes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this