Abstract
Certain diseases are more prevalent among women than men. The reasons for this increased prevalence are unknown, but there could be a genetic basis. Increased expression of X-linked genes in females, protective effects of Y-linked genes in males, or sex-limited gene expression that is developmentally or hormonally regulated could all account for these differences. Analysis of individuals with and without genetic sex reversal provides a means for distinguishing between genetic and hormonal causes. This can be complemented by genetic linkage and gene expression profiling to aid in the identification of candidate genes.
Original language | English (US) |
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Pages (from-to) | 2384-2388 |
Number of pages | 5 |
Journal | Journal of applied physiology |
Volume | 91 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Sex determination
- Sex-limited gene expression
- X-linked genes
- Y-linked genes
ASJC Scopus subject areas
- Physiology
- Physiology (medical)