Genome and hormones

Gender differences in physiology invited review: Sex-based differences in gene expression

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Certain diseases are more prevalent among women than men. The reasons for this increased prevalence are unknown, but there could be a genetic basis. Increased expression of X-linked genes in females, protective effects of Y-linked genes in males, or sex-limited gene expression that is developmentally or hormonally regulated could all account for these differences. Analysis of individuals with and without genetic sex reversal provides a means for distinguishing between genetic and hormonal causes. This can be complemented by genetic linkage and gene expression profiling to aid in the identification of candidate genes.

Original languageEnglish (US)
Pages (from-to)2384-2388
Number of pages5
JournalJournal of Applied Physiology
Volume91
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Sex Characteristics
Y-Linked Genes
Genome
Hormones
Gene Expression
X-Linked Genes
Genetic Linkage
Genetic Association Studies
Gene Expression Profiling

Keywords

  • Sex determination
  • Sex-limited gene expression
  • X-linked genes
  • Y-linked genes

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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