Genetics of type 2 diabetes in European populations

Qibin Qi, Frank B. Hu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Type 2 diabetes (T2D) has become a leading health problem throughout the world. It is caused by environmental and genetic factors, as well as interactions between the two. However, until very recently, the T2D susceptibility genes have been poorly understood. During the past 5years, with the advent of genome-wide association studies (GWAS), a total of 58 T2D susceptibility loci have been associated with T2D risk at a genome-wide significance level (P<5×10-8), with evidence showing that most of these genetic variants influence pancreatic β-cell function. Most novel T2D susceptibility loci were identified through GWAS in European populations and later confirmed in other ethnic groups. Although the recent discovery of novel T2D susceptibility loci has contributed substantially to our understanding of the pathophysiology of the disease, the clinical utility of these loci in disease prediction and prognosis is limited. More studies using multi-ethnic meta-analysis, gene-environment interaction analysis, sequencing analysis, epigenetic analysis, and functional experiments are needed to identify new susceptibility T2D loci and causal variants, and to establish biological mechanisms.

Original languageEnglish (US)
Pages (from-to)203-212
Number of pages10
JournalJournal of Diabetes
Volume4
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Population
Genome-Wide Association Study
Gene-Environment Interaction
Ethnic Groups
Epigenomics
Meta-Analysis
Genome
Health
Genes

Keywords

  • Europeans
  • Genetics
  • Genome-wide association studies
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Genetics of type 2 diabetes in European populations. / Qi, Qibin; Hu, Frank B.

In: Journal of Diabetes, Vol. 4, No. 3, 09.2012, p. 203-212.

Research output: Contribution to journalArticle

Qi, Qibin ; Hu, Frank B. / Genetics of type 2 diabetes in European populations. In: Journal of Diabetes. 2012 ; Vol. 4, No. 3. pp. 203-212.
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