Abstract
In summary, the meeting was a good reflection of the significant progress that has been made in the elucidation of the genetic component of aging. Probably the most intriguing findings involve the demonstrated possibility that aging and life span can be manipulated using single genes, and that these genes appear to be part of functional pathways involved in either basal metabolism or some aspect of DNA processing. This suggests that metabolically derived somatic damage may drive post-reproductive senescence. Thus far, the main players in this field have been model organisms. However, the next stage could well be dominated by large-scale population-based studies to identify the relevant pathways directly in the human, and establish gene-gene and gene-environment interactions. Nevertheless, model organisms, both invertebrates and vertebrates, will remain indispensable for gene functionalization studies and for testing novel gene variants.
| Original language | English (US) |
|---|---|
| Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
| Volume | 1423 |
| Issue number | 1 |
| State | Published - Jan 29 1999 |
| Externally published | Yes |
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Keywords
- (Caenorhabditis elegans)
- Genome stability system
- Replicative senescence
- Telomerase
- Werner syndrome
- Yeast
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Biophysics
Cite this
Genetics of aging sponsored by Cold Spring Harbor Laboratory, 2-5 April 1998. / Vijg, Jan.
In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1423, No. 1, 29.01.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetics of aging sponsored by Cold Spring Harbor Laboratory, 2-5 April 1998
AU - Vijg, Jan
PY - 1999/1/29
Y1 - 1999/1/29
N2 - In summary, the meeting was a good reflection of the significant progress that has been made in the elucidation of the genetic component of aging. Probably the most intriguing findings involve the demonstrated possibility that aging and life span can be manipulated using single genes, and that these genes appear to be part of functional pathways involved in either basal metabolism or some aspect of DNA processing. This suggests that metabolically derived somatic damage may drive post-reproductive senescence. Thus far, the main players in this field have been model organisms. However, the next stage could well be dominated by large-scale population-based studies to identify the relevant pathways directly in the human, and establish gene-gene and gene-environment interactions. Nevertheless, model organisms, both invertebrates and vertebrates, will remain indispensable for gene functionalization studies and for testing novel gene variants.
AB - In summary, the meeting was a good reflection of the significant progress that has been made in the elucidation of the genetic component of aging. Probably the most intriguing findings involve the demonstrated possibility that aging and life span can be manipulated using single genes, and that these genes appear to be part of functional pathways involved in either basal metabolism or some aspect of DNA processing. This suggests that metabolically derived somatic damage may drive post-reproductive senescence. Thus far, the main players in this field have been model organisms. However, the next stage could well be dominated by large-scale population-based studies to identify the relevant pathways directly in the human, and establish gene-gene and gene-environment interactions. Nevertheless, model organisms, both invertebrates and vertebrates, will remain indispensable for gene functionalization studies and for testing novel gene variants.
KW - (Caenorhabditis elegans)
KW - Genome stability system
KW - Replicative senescence
KW - Telomerase
KW - Werner syndrome
KW - Yeast
UR - http://www.scopus.com/inward/record.url?scp=0033613685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033613685&partnerID=8YFLogxK
M3 - Article
C2 - 9989209
AN - SCOPUS:0033613685
VL - 1423
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 1
ER -