Genetics of acute respiratory distress syndrome: Challenges, approaches, surfactant proteins as candidate genes

Joanna Floros, Jelena Pavlovic

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

There are challenges "inherent" in studying the genetics of a complex disease, such as acute respiratory distress syndrome (ARDS). It is necessary to define each ARDS subgroup using considerably narrower definitions that better reflect the particular subgroup. ARDS consists of several phenotypic subgroups, and findings from one subgroup may not be applicable to another. By extension, different treatment therapies may be appropriate for each phenotypic subgroup. This article presents the findings of a small pilot case-control association study where the surfactant proteins were used as candidate genes in the study of ARDS. This article discusses the relevance of surfactant protein genes in ARDS as well as the significance of genetic variants associated with ARDS subgroups.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalSeminars in Respiratory and Critical Care Medicine
Volume24
Issue number2
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Keywords

  • Case-control study
  • Genetic variants
  • Multigenic
  • SP-A
  • Surfactant protein B (SP-B)
  • Transmission disequilibrium test (TDT)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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