Genetically determined sex-reversal in 46,XY humans

James German; Joe Leigh Simpson; R. S.K. Chaganti; Robert L. Summitt; Lloyene Bruce Reid; Irwin R. Merkatz

doi:10.1126/science.567843

Genetically determined sex-reversal in 46,XY humans

James German, Joe Leigh Simpson, R. S.K. Chaganti, Robert L. Summitt, Lloyene Bruce Reid, Irwin R. Merkatz

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similar to those of 45,X women.

Original language	English (US)
Pages (from-to)	53-56
Number of pages	4
Journal	Science
Volume	202
Issue number	4363
DOIs	https://doi.org/10.1126/science.567843
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.567843

Cite this

@article{0f2eaceabe0f436fbf7ca2cdd3f004ac,

title = "Genetically determined sex-reversal in 46,XY humans",

abstract = "Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have {"}streak gonads{"} similar to those of 45,X women.",

author = "James German and Simpson, {Joe Leigh} and Chaganti, {R. S.K.} and Summitt, {Robert L.} and Reid, {Lloyene Bruce} and Merkatz, {Irwin R.}",

year = "1978",

doi = "10.1126/science.567843",

language = "English (US)",

volume = "202",

pages = "53--56",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4363",

}

TY - JOUR

T1 - Genetically determined sex-reversal in 46,XY humans

AU - German, James

AU - Simpson, Joe Leigh

AU - Chaganti, R. S.K.

AU - Summitt, Robert L.

AU - Reid, Lloyene Bruce

AU - Merkatz, Irwin R.

PY - 1978

Y1 - 1978

N2 - Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similar to those of 45,X women.

AB - Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similar to those of 45,X women.

UR - http://www.scopus.com/inward/record.url?scp=0018262106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018262106&partnerID=8YFLogxK

U2 - 10.1126/science.567843

DO - 10.1126/science.567843

M3 - Article

C2 - 567843

AN - SCOPUS:0018262106

SN - 0036-8075

VL - 202

SP - 53

EP - 56

JO - Science

JF - Science

IS - 4363

ER -

Genetically determined sex-reversal in 46,XY humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this