Genetically determined sex-reversal in 46,XY humans

James German, Joe Leigh Simpson, R. S K Chaganti, Robert L. Summitt, Lloyene Bruce Reid, Irwin R. Merkatz

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similar to those of 45,X women.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalScience
Volume202
Issue number4363
StatePublished - 1978
Externally publishedYes

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Gonads
X Chromosome
Testis
Embryonic Structures
Genes

ASJC Scopus subject areas

  • General

Cite this

German, J., Simpson, J. L., Chaganti, R. S. K., Summitt, R. L., Reid, L. B., & Merkatz, I. R. (1978). Genetically determined sex-reversal in 46,XY humans. Science, 202(4363), 53-56.

Genetically determined sex-reversal in 46,XY humans. / German, James; Simpson, Joe Leigh; Chaganti, R. S K; Summitt, Robert L.; Reid, Lloyene Bruce; Merkatz, Irwin R.

In: Science, Vol. 202, No. 4363, 1978, p. 53-56.

Research output: Contribution to journalArticle

German, J, Simpson, JL, Chaganti, RSK, Summitt, RL, Reid, LB & Merkatz, IR 1978, 'Genetically determined sex-reversal in 46,XY humans', Science, vol. 202, no. 4363, pp. 53-56.
German J, Simpson JL, Chaganti RSK, Summitt RL, Reid LB, Merkatz IR. Genetically determined sex-reversal in 46,XY humans. Science. 1978;202(4363):53-56.
German, James ; Simpson, Joe Leigh ; Chaganti, R. S K ; Summitt, Robert L. ; Reid, Lloyene Bruce ; Merkatz, Irwin R. / Genetically determined sex-reversal in 46,XY humans. In: Science. 1978 ; Vol. 202, No. 4363. pp. 53-56.
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