Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma

Qing Lan; Tongzhang Zheng; Stephen Chanock; Yawei Zhang; Min Shen; Sophia S. Wang; Sonja I. Berndt; Shelia H. Zahm; Theodore R. Holford; Brian Leaderer; Meredith Yeager; Robert Welch; Dean Hosgood; Peter Boyle; Nathaniel Rothman

doi:10.1093/carcin/bgl196

Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma

Qing Lan, Tongzhang Zheng, Stephen Chanock, Yawei Zhang, Min Shen, Sophia S. Wang, Sonja I. Berndt, Shelia H. Zahm, Theodore R. Holford, Brian Leaderer, Meredith Yeager, Robert Welch, Dean Hosgood, Peter Boyle, Nathaniel Rothman

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR) CC+TC = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR AA+AG = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL.

Original language	English (US)
Pages (from-to)	823-827
Number of pages	5
Journal	Carcinogenesis
Volume	28
Issue number	4
DOIs	https://doi.org/10.1093/carcin/bgl196
State	Published - Apr 2007
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/carcin/bgl196

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@article{cd9db923b7904190b9abdef2d4964555,

title = "Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma",

abstract = "The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR) CC+TC = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR AA+AG = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL.",

author = "Qing Lan and Tongzhang Zheng and Stephen Chanock and Yawei Zhang and Min Shen and Wang, {Sophia S.} and Berndt, {Sonja I.} and Zahm, {Shelia H.} and Holford, {Theodore R.} and Brian Leaderer and Meredith Yeager and Robert Welch and Dean Hosgood and Peter Boyle and Nathaniel Rothman",

note = "Funding Information: This study was supported in part by the Intramural Research Program of the NIH, National Cancer Institute and NIH grant CA62006 from the National Cancer Institute. We gratefully acknowledge the assistance of Peter Hui (Information Management Services, Inc., Silver Spring, MD) for programming support.",

year = "2007",

month = apr,

doi = "10.1093/carcin/bgl196",

language = "English (US)",

volume = "28",

pages = "823--827",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "4",

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TY - JOUR

T1 - Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma

AU - Lan, Qing

AU - Zheng, Tongzhang

AU - Chanock, Stephen

AU - Zhang, Yawei

AU - Shen, Min

AU - Wang, Sophia S.

AU - Berndt, Sonja I.

AU - Zahm, Shelia H.

AU - Holford, Theodore R.

AU - Leaderer, Brian

AU - Yeager, Meredith

AU - Welch, Robert

AU - Hosgood, Dean

AU - Boyle, Peter

AU - Rothman, Nathaniel

N1 - Funding Information: This study was supported in part by the Intramural Research Program of the NIH, National Cancer Institute and NIH grant CA62006 from the National Cancer Institute. We gratefully acknowledge the assistance of Peter Hui (Information Management Services, Inc., Silver Spring, MD) for programming support.

PY - 2007/4

Y1 - 2007/4

N2 - The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR) CC+TC = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR AA+AG = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL.

AB - The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR) CC+TC = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR AA+AG = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL.

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U2 - 10.1093/carcin/bgl196

DO - 10.1093/carcin/bgl196

M3 - Article

C2 - 17071630

AN - SCOPUS:34047141698

SN - 0143-3334

VL - 28

SP - 823

EP - 827

JO - Carcinogenesis

JF - Carcinogenesis

IS - 4

ER -

Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma

Abstract

ASJC Scopus subject areas

UN SDGs

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