Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes

Two independent studies

Qibin Qi, John P. Forman, Majken K. Jensen, Alan Flint, Gary C. Curhan, Eric B. Rimm, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals with T2D. The current study included 1,005 men and 1,299 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, of whom 732 developed CVD. A genetic predisposition score was calculated on the basis of 29 established blood pressure-associated variants. The genetic predisposition score showed consistent associations with risk of CVD in men and women. In the combined results, each additional blood pressure-increasing allele was associated with a 6% increased risk of CVD (odds ratio [OR] 1.06 [95% CI 1.03-1.10]). The OR was 1.62 (1.22-2.14) for risk of CVD comparing the extreme quartiles of the genetic predisposition score. The genetic association for CVD risk was significantly stronger in patients with T2D than that estimated in the general populations by a meta-analysis (OR per SD of genetic score 1.22 [95% CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I2 = 71%). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D.

Original languageEnglish (US)
Pages (from-to)3026-3032
Number of pages7
JournalDiabetes
Volume61
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Genetic Predisposition to Disease
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Hypertension
Odds Ratio
Blood Pressure
Health
Meta-Analysis
Alleles
Nurses
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes : Two independent studies. / Qi, Qibin; Forman, John P.; Jensen, Majken K.; Flint, Alan; Curhan, Gary C.; Rimm, Eric B.; Hu, Frank B.; Qi, Lu.

In: Diabetes, Vol. 61, No. 11, 11.2012, p. 3026-3032.

Research output: Contribution to journalArticle

Qi, Qibin ; Forman, John P. ; Jensen, Majken K. ; Flint, Alan ; Curhan, Gary C. ; Rimm, Eric B. ; Hu, Frank B. ; Qi, Lu. / Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes : Two independent studies. In: Diabetes. 2012 ; Vol. 61, No. 11. pp. 3026-3032.
@article{dcf438ec565c45399b29de736e8fd6bf,
title = "Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes: Two independent studies",
abstract = "Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals with T2D. The current study included 1,005 men and 1,299 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, of whom 732 developed CVD. A genetic predisposition score was calculated on the basis of 29 established blood pressure-associated variants. The genetic predisposition score showed consistent associations with risk of CVD in men and women. In the combined results, each additional blood pressure-increasing allele was associated with a 6{\%} increased risk of CVD (odds ratio [OR] 1.06 [95{\%} CI 1.03-1.10]). The OR was 1.62 (1.22-2.14) for risk of CVD comparing the extreme quartiles of the genetic predisposition score. The genetic association for CVD risk was significantly stronger in patients with T2D than that estimated in the general populations by a meta-analysis (OR per SD of genetic score 1.22 [95{\%} CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I2 = 71{\%}). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D.",
author = "Qibin Qi and Forman, {John P.} and Jensen, {Majken K.} and Alan Flint and Curhan, {Gary C.} and Rimm, {Eric B.} and Hu, {Frank B.} and Lu Qi",
year = "2012",
month = "11",
doi = "10.2337/db12-0225",
language = "English (US)",
volume = "61",
pages = "3026--3032",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "11",

}

TY - JOUR

T1 - Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes

T2 - Two independent studies

AU - Qi, Qibin

AU - Forman, John P.

AU - Jensen, Majken K.

AU - Flint, Alan

AU - Curhan, Gary C.

AU - Rimm, Eric B.

AU - Hu, Frank B.

AU - Qi, Lu

PY - 2012/11

Y1 - 2012/11

N2 - Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals with T2D. The current study included 1,005 men and 1,299 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, of whom 732 developed CVD. A genetic predisposition score was calculated on the basis of 29 established blood pressure-associated variants. The genetic predisposition score showed consistent associations with risk of CVD in men and women. In the combined results, each additional blood pressure-increasing allele was associated with a 6% increased risk of CVD (odds ratio [OR] 1.06 [95% CI 1.03-1.10]). The OR was 1.62 (1.22-2.14) for risk of CVD comparing the extreme quartiles of the genetic predisposition score. The genetic association for CVD risk was significantly stronger in patients with T2D than that estimated in the general populations by a meta-analysis (OR per SD of genetic score 1.22 [95% CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I2 = 71%). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D.

AB - Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals with T2D. The current study included 1,005 men and 1,299 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, of whom 732 developed CVD. A genetic predisposition score was calculated on the basis of 29 established blood pressure-associated variants. The genetic predisposition score showed consistent associations with risk of CVD in men and women. In the combined results, each additional blood pressure-increasing allele was associated with a 6% increased risk of CVD (odds ratio [OR] 1.06 [95% CI 1.03-1.10]). The OR was 1.62 (1.22-2.14) for risk of CVD comparing the extreme quartiles of the genetic predisposition score. The genetic association for CVD risk was significantly stronger in patients with T2D than that estimated in the general populations by a meta-analysis (OR per SD of genetic score 1.22 [95% CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I2 = 71%). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D.

UR - http://www.scopus.com/inward/record.url?scp=84868018760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868018760&partnerID=8YFLogxK

U2 - 10.2337/db12-0225

DO - 10.2337/db12-0225

M3 - Article

VL - 61

SP - 3026

EP - 3032

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 11

ER -