Genetic predisposition to central obesity and risk of type 2 diabetes: Two independent cohort studies

Tao Huang, Qibin Qi, Yan Zheng, Sylvia H. Ley, Jo Ann E. Manson, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

15 Scopus citations


OBJECTIVE: Abdominal obesity is a major risk factor for type 2 diabetes (T2D). We aimed to examine the association between the genetic predisposition to central obesity, assessed by the waist-to-hip ratio (WHR) genetic score, and T2D risk. RESEARCH DESIGN AND METHODS: The current study included 2,591 participants with T2D and 3,052 participants without T2D of European ancestry from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Genetic predisposition to central obesity was estimated using a genetic score based on 14 established loci for the WHR. RESULTS: We found that the central obesity genetic score was linearly related to higher T2D risk. Results were similar in the NHS (women) and HPFS (men). In combined results, each point of the central obesity genetic score was associated with an odds ratio (OR) of 1.04 (95% CI 1.01-1.07) for developing T2D, and the OR was 1.24 (1.03-1.45) when comparing extreme quartiles of the genetic score after multivariate adjustment. CONCLUSIONS: The data indicate that genetic predisposition to central obesity is associated with higher T2D risk. This association is mediated by central obesity.

Original languageEnglish (US)
Pages (from-to)1306-1311
Number of pages6
JournalDiabetes care
Issue number7
StatePublished - Jul 2015


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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