Genetic polymorphism of human plasminogen

D. Raum, D. Marcus, C. A. Alper

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen has been delineated. Two alleles PLGN(A) and PLGN(B), were observed with gene frequencies in whites of .69 and .30; in Orientals of 0.96 and .03; and in blacks of .80 and .18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.

Original languageEnglish (US)
Pages (from-to)681-689
Number of pages9
JournalAmerican Journal of Human Genetics
Volume32
Issue number5
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Raum, D., Marcus, D., & Alper, C. A. (1980). Genetic polymorphism of human plasminogen. American Journal of Human Genetics, 32(5), 681-689.