TY - JOUR
T1 - Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population
T2 - DG8S737 may not be the causative variant
AU - Zeegers, Maurice P.
AU - Khan, Humera S.
AU - Schouten, Leo J.
AU - Van Dijk, Boukje A.C.
AU - Goldbohm, R. Alexandra
AU - Schalken, Jack
AU - Shajahan, Shahin
AU - Pearlman, Alexander
AU - Oddoux, Carole
AU - Van Den Brandt, Piet A.
AU - Ostrer, Harry
N1 - Funding Information:
This study was established with financial support from the Dutch Cancer Society and the US Department of Defense.
PY - 2011/1
Y1 - 2011/1
N2 - Prostate cancer is the most commonly diagnosed cancer in men in Europe and Northern America. Genome-wide association studies (GWAS) have detected an association with markers on chromosome 8q24. Allele-8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer. As GWAS are subjected to type 1 error, confirmation studies are required to validate the results. Here, we analysed the same markers in 277 cases and 282 controls from the Netherlands using a nested case-control study. Incident prostate cancer cases and controls selected were identified in the population of the Netherlands Cohort Study. We also investigated clinical features of the disease by stratifying by tumour stage. We did not replicate the association with the SNP rs1447295-A allele (P=0.10), although the effect estimate was in the same direction as previous studies (odds ratio (OR), 1.38). Interestingly a statistically significant decreased risk was observed for DG8S737 allele-8 (OR, 0.62; P=0.03). The apparent protective effect of the DG8S737-8 allele observed in this study contrasts with the Amundadottir study. This suggests that DG8S737 and rs1447295 might be tightly linked markers flanking the actual causative variant and that there may be potentially more than one high-risk haplotype present in the Caucasian population. This short report highlights the importance of validation, although further confirmation is still needed.
AB - Prostate cancer is the most commonly diagnosed cancer in men in Europe and Northern America. Genome-wide association studies (GWAS) have detected an association with markers on chromosome 8q24. Allele-8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer. As GWAS are subjected to type 1 error, confirmation studies are required to validate the results. Here, we analysed the same markers in 277 cases and 282 controls from the Netherlands using a nested case-control study. Incident prostate cancer cases and controls selected were identified in the population of the Netherlands Cohort Study. We also investigated clinical features of the disease by stratifying by tumour stage. We did not replicate the association with the SNP rs1447295-A allele (P=0.10), although the effect estimate was in the same direction as previous studies (odds ratio (OR), 1.38). Interestingly a statistically significant decreased risk was observed for DG8S737 allele-8 (OR, 0.62; P=0.03). The apparent protective effect of the DG8S737-8 allele observed in this study contrasts with the Amundadottir study. This suggests that DG8S737 and rs1447295 might be tightly linked markers flanking the actual causative variant and that there may be potentially more than one high-risk haplotype present in the Caucasian population. This short report highlights the importance of validation, although further confirmation is still needed.
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U2 - 10.1038/ejhg.2010.133
DO - 10.1038/ejhg.2010.133
M3 - Article
C2 - 20700145
AN - SCOPUS:78650045249
SN - 1018-4813
VL - 19
SP - 118
EP - 120
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 1
ER -