GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS

Donald Douglas Raum, C. A. Alper, R. Stein, K. H. Gabbay

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

A rare genetic type (Bf F1) of properdin factor B is found in 22·6% of patients with insulin-dependent diabetes mellitus but in only 1·9% of the general population, yielding a relative risk of 15·0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.

Original languageEnglish (US)
Pages (from-to)1208-1210
Number of pages3
JournalThe Lancet
Volume313
Issue number8128
DOIs
StatePublished - Jun 9 1979
Externally publishedYes

Fingerprint

Type 1 Diabetes Mellitus
Genetic Markers
Chromosomes, Human, Pair 6
Genetic Loci
Complement Factor B
Insulin
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS. / Raum, Donald Douglas; Alper, C. A.; Stein, R.; Gabbay, K. H.

In: The Lancet, Vol. 313, No. 8128, 09.06.1979, p. 1208-1210.

Research output: Contribution to journalArticle

Raum, DD, Alper, CA, Stein, R & Gabbay, KH 1979, 'GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS', The Lancet, vol. 313, no. 8128, pp. 1208-1210. https://doi.org/10.1016/S0140-6736(79)91895-6
Raum, Donald Douglas ; Alper, C. A. ; Stein, R. ; Gabbay, K. H. / GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS. In: The Lancet. 1979 ; Vol. 313, No. 8128. pp. 1208-1210.
@article{3a97a5ba7d474ef7aabd0a6653f7a518,
title = "GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS",
abstract = "A rare genetic type (Bf F1) of properdin factor B is found in 22·6{\%} of patients with insulin-dependent diabetes mellitus but in only 1·9{\%} of the general population, yielding a relative risk of 15·0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.",
author = "Raum, {Donald Douglas} and Alper, {C. A.} and R. Stein and Gabbay, {K. H.}",
year = "1979",
month = "6",
day = "9",
doi = "10.1016/S0140-6736(79)91895-6",
language = "English (US)",
volume = "313",
pages = "1208--1210",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8128",

}

TY - JOUR

T1 - GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS

AU - Raum, Donald Douglas

AU - Alper, C. A.

AU - Stein, R.

AU - Gabbay, K. H.

PY - 1979/6/9

Y1 - 1979/6/9

N2 - A rare genetic type (Bf F1) of properdin factor B is found in 22·6% of patients with insulin-dependent diabetes mellitus but in only 1·9% of the general population, yielding a relative risk of 15·0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.

AB - A rare genetic type (Bf F1) of properdin factor B is found in 22·6% of patients with insulin-dependent diabetes mellitus but in only 1·9% of the general population, yielding a relative risk of 15·0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.

UR - http://www.scopus.com/inward/record.url?scp=0018785670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018785670&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(79)91895-6

DO - 10.1016/S0140-6736(79)91895-6

M3 - Article

VL - 313

SP - 1208

EP - 1210

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8128

ER -