Genetic interactions between Drosophila melanogaster menin and Jun/Fos

Aniello Cerrato, Michael Parisi, Sonia Santa Anna, Fanis Missirlis, Siradanahalli Guru, Sunita Agarwal, David Sturgill, Thomas Talbot, Allen Spiegel, Francis Collins, Settara Chandrasekharappa, Stephen Marx, Brian Oliver

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Menin is a tumor suppressor required to prevent multiple endocrine neoplasia in humans. Mammalian menin protein is associated with chromatin modifying complexes and has been shown to bind a number of nuclear proteins, including the transcription factor JunD. Menin shows bidirectional effects acting positively on c-Jun and negatively on JunD. We have produced protein null alleles of Drosophila menin (mnn1) and have over expressed the Mnn1 protein. Flies homozygous for protein-null mnn1 alleles are viable and fertile. Localized over-expression of Mnn1 causes defects in thoracic closure, a phenotype that sometimes results from insufficient Jun activity. We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalDevelopmental Biology
Volume298
Issue number1
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • AP1
  • Cleft thorax
  • Life span
  • Multiple endocrine neoplasia type I
  • Oxidative stress
  • Paraquat
  • Tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Genetic interactions between Drosophila melanogaster menin and Jun/Fos'. Together they form a unique fingerprint.

  • Cite this

    Cerrato, A., Parisi, M., Anna, S. S., Missirlis, F., Guru, S., Agarwal, S., Sturgill, D., Talbot, T., Spiegel, A., Collins, F., Chandrasekharappa, S., Marx, S., & Oliver, B. (2006). Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Developmental Biology, 298(1), 59-70. https://doi.org/10.1016/j.ydbio.2006.06.013