Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia

Rui Zhang, Shemin Lu, Liesu Meng, Zixin Min, Juan Tian, Robert K. Valenzuela, Tingwei Guo, Lifang Tian, Wenxiang Zhao, Jie Ma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recently, two genome scan meta-analysis studies have found strong evidence for the association of loci on chromosome 8p with schizophrenia. The early growth response 3 (EGR3) gene located in chromosome 8p21.3 was also found to be involved in the etiology of schizophrenia. However, subsequent studies failed to replicate this finding. To investigate the genetic role of EGR3 in Chinese patients, we genotyped four SNPs (average interval ~2.3 kb) in the chromosome region of EGR3 in 470 Chinese schizophrenia patients and 480 healthy control subjects. The SNP rs35201266 (located in intron 1 of EGR3) showed significant differences between cases and controls in both genotype frequency distribution (P = 0.016) and allele frequency distribution (P = 0.009). Analysis of the haplotype rs35201266-rs3750192 provided significant evidence for association with schizophrenia (P = 0.0012); a significant difference was found for the common haplotype AG (P = 0.0005). Furthermore, significant associations were also found in several other two-, and three-SNP tests of haplotype analyses. The meta-analysis revealed a statistically significant association between rs35201266 and schizophrenia (P = 0.0001). In summary, our study supports the association of EGR3 with schizophrenia in our Han Chinese sample, and further functional exploration of the EGR3 gene will contribute to the molecular basis for the complex network underlying schizophrenia pathogenesis.

Original languageEnglish (US)
Article numbere30237
JournalPLoS One
Volume7
Issue number1
DOIs
StatePublished - Jan 20 2012

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Schizophrenia
Genes
Chromosomes
Growth
Haplotypes
genes
Single Nucleotide Polymorphism
haplotypes
chromosomes
meta-analysis
Meta-Analysis
Complex networks
Introns
schizophrenia
Gene Frequency
gene frequency
etiology
introns
Healthy Volunteers
pathogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zhang, R., Lu, S., Meng, L., Min, Z., Tian, J., Valenzuela, R. K., ... Ma, J. (2012). Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. PLoS One, 7(1), [e30237]. https://doi.org/10.1371/journal.pone.0030237

Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. / Zhang, Rui; Lu, Shemin; Meng, Liesu; Min, Zixin; Tian, Juan; Valenzuela, Robert K.; Guo, Tingwei; Tian, Lifang; Zhao, Wenxiang; Ma, Jie.

In: PLoS One, Vol. 7, No. 1, e30237, 20.01.2012.

Research output: Contribution to journalArticle

Zhang, R, Lu, S, Meng, L, Min, Z, Tian, J, Valenzuela, RK, Guo, T, Tian, L, Zhao, W & Ma, J 2012, 'Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia', PLoS One, vol. 7, no. 1, e30237. https://doi.org/10.1371/journal.pone.0030237
Zhang, Rui ; Lu, Shemin ; Meng, Liesu ; Min, Zixin ; Tian, Juan ; Valenzuela, Robert K. ; Guo, Tingwei ; Tian, Lifang ; Zhao, Wenxiang ; Ma, Jie. / Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. In: PLoS One. 2012 ; Vol. 7, No. 1.
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