Genetic evidence for common pathways in human age-related diseases

Simon C. Johnson, Xiao Dong, Jan Vijg, Yousin Suh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Aging is the single largest risk factor for chronic disease. Studies in model organisms have identified conserved pathways that modulate aging rate and the onset and progression of multiple age-related diseases, suggesting that common pathways of aging may influence age-related diseases in humans as well. To determine whether there is genetic evidence supporting the notion of common pathways underlying age-related diseases, we analyzed the genes and pathways found to be associated with five major categories of age-related disease using a total of 410 genomewide association studies (GWAS). While only a small number of genes are shared among all five disease categories, those found in at least three of the five major age-related disease categories are highly enriched for apoliprotein metabolism genes. We found that a more substantial number of gene ontology (GO) terms are shared among the 5 age-related disease categories and shared GO terms include canonical aging pathways identified in model organisms, such as nutrient-sensing signaling, translation, proteostasis, stress responses, and genome maintenance. Taking advantage of the vast amount of genetic data from the GWAS, our findings provide the first direct evidence that conserved pathways of aging simultaneously influence multiple age-related diseases in humans as has been demonstrated in model organisms.

Original languageEnglish (US)
Pages (from-to)809-817
Number of pages9
JournalAging Cell
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2015

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Gene Ontology
Genes
Chronic Disease
Maintenance
Genome
Food

Keywords

  • Ageing
  • Aging
  • Genetics
  • Gerontogenes
  • Human
  • Inflammation
  • Ink4a
  • Longevity gene

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Genetic evidence for common pathways in human age-related diseases. / Johnson, Simon C.; Dong, Xiao; Vijg, Jan; Suh, Yousin.

In: Aging Cell, Vol. 14, No. 5, 01.10.2015, p. 809-817.

Research output: Contribution to journalArticle

Johnson, Simon C. ; Dong, Xiao ; Vijg, Jan ; Suh, Yousin. / Genetic evidence for common pathways in human age-related diseases. In: Aging Cell. 2015 ; Vol. 14, No. 5. pp. 809-817.
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