Genetic Epidemiology of Acute Respiratory Distress Syndrome

Implications for Future Prevention and Treatment

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The application of genetic epidemiology and genomics to the study of ALI/ARDS is in its infancy. Optimal study designs and approaches are still being discussed, and the large, prospective cohorts that will be necessary to examine gene-environment interaction and to confirm prior findings are being developed. There will be technological and analytic challenges to the proper study of genetic determinants of ALI/ARDS that will benefit from a multifaceted approach. There will be significant barriers to the translation of genetic epidemiology studies and genomics to preventive and therapeutic interventions, and any intervention is unlikely to occur in the near future. In oncology, where there is a longer history of genetic and molecular epidemiology studies, commercially available genetic tests now allow individualized risk assessment and tailored therapy for breast cancer. Although significant challenges lie ahead, there is a similar potential for such individualized risk assessment and therapy in critical care medicine. Large, well-phenotyped studies will be crucial to this goal.

Original languageEnglish (US)
Pages (from-to)705-724
Number of pages20
JournalClinics in Chest Medicine
Volume27
Issue number4
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Molecular Epidemiology
Adult Respiratory Distress Syndrome
Genomics
Gene-Environment Interaction
Therapeutics
Critical Care
Medicine
Breast Neoplasms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "The application of genetic epidemiology and genomics to the study of ALI/ARDS is in its infancy. Optimal study designs and approaches are still being discussed, and the large, prospective cohorts that will be necessary to examine gene-environment interaction and to confirm prior findings are being developed. There will be technological and analytic challenges to the proper study of genetic determinants of ALI/ARDS that will benefit from a multifaceted approach. There will be significant barriers to the translation of genetic epidemiology studies and genomics to preventive and therapeutic interventions, and any intervention is unlikely to occur in the near future. In oncology, where there is a longer history of genetic and molecular epidemiology studies, commercially available genetic tests now allow individualized risk assessment and tailored therapy for breast cancer. Although significant challenges lie ahead, there is a similar potential for such individualized risk assessment and therapy in critical care medicine. Large, well-phenotyped studies will be crucial to this goal.",
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