TY - JOUR
T1 - Genetic epidemiologic studies of preterm birth
T2 - guidelines for research
AU - Pennell, Craig E.
AU - Jacobsson, Bo
AU - Williams, Scott M.
AU - Buus, Rebecca M.
AU - Muglia, Louis J.
AU - Dolan, Siobhan M.
AU - Morken, Nils Halvdan
AU - Ozcelik, Hilmi
AU - Lye, Stephen J.
AU - Relton, Caroline
N1 - Funding Information:
This study was supported by The University of Western Australia; the Thrasher Research Foundation; the March of Dimes Birth Defects Foundation, White Plains, NY; and the Westlakes Research Institute.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - Over the last decade, it has become increasingly apparent that the cause of preterm birth is multifactorial, involving both genetic and environmental factors. With the development of new technologies capable of probing the genome, exciting possibilities now present themselves to gain new insight into the mechanisms leading to preterm birth. This review aims to develop research guidelines for the conduct of genetic epidemiology studies of preterm birth with the expectation that this will ultimately facilitate the comparison of data sets between study cohorts, both nationally and internationally. Specifically, the 4 areas addressed in this review includes: (1) phenotypic criteria, (2) study design, (3) considerations in the selection of control populations, and (4) candidate gene selection. This article is the product of discussions initiated by the authors at the 3rd International Workshop on Biomarkers and Preterm Birth held at the University of California, Los Angeles, Los Angeles, CA, in March 2005.
AB - Over the last decade, it has become increasingly apparent that the cause of preterm birth is multifactorial, involving both genetic and environmental factors. With the development of new technologies capable of probing the genome, exciting possibilities now present themselves to gain new insight into the mechanisms leading to preterm birth. This review aims to develop research guidelines for the conduct of genetic epidemiology studies of preterm birth with the expectation that this will ultimately facilitate the comparison of data sets between study cohorts, both nationally and internationally. Specifically, the 4 areas addressed in this review includes: (1) phenotypic criteria, (2) study design, (3) considerations in the selection of control populations, and (4) candidate gene selection. This article is the product of discussions initiated by the authors at the 3rd International Workshop on Biomarkers and Preterm Birth held at the University of California, Los Angeles, Los Angeles, CA, in March 2005.
KW - candidate gene
KW - control population
KW - genetic association study
KW - genotype
KW - phenotype
KW - preterm premature rupture of membranes
KW - single nucleotide polymorphism
KW - study design
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U2 - 10.1016/j.ajog.2006.03.109
DO - 10.1016/j.ajog.2006.03.109
M3 - Review article
C2 - 17306646
AN - SCOPUS:33846940547
SN - 0002-9378
VL - 196
SP - 107
EP - 118
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -