TY - JOUR
T1 - Genetic dissection of familial autoimmune thyroid diseases using whole genome screening
AU - Tomer, Yaron
N1 - Funding Information:
We thank Dr David Greenberg for his teaching, support and ever-ready help in our joint studies. We also thank Erlinda Concepcion for her exceptional technical support. Our studies were supported in part by: DK35764, DK45011 and DK52464 from NIDDK (to TFD); and DK02498 and DK58072 from NIDDK (to YT).
PY - 2002/8/1
Y1 - 2002/8/1
N2 - The autoimmune thyroid diseases (AITDs) are multifactorial disease which are caused by genetic susceptibility and environmental triggers. Various epidemiological and genetic techniques can be employed to study the genetic contribution to disease development. Most epidemiologic data support an important genetic contribution to the development of AITD. The genetic susceptibility to AITD involves several genes with varying effects. Some AITD susceptibility genes are most likely immune modifying genes which increase the susceptibility to autoimmunity in general (e.g. HLA, CTLA-4) while others may be thyroid-specific (e.g. thyroglobulin). These genes probably act in concert to increase the autoimmune reactions in susceptible individuals and direct them towards the thyroid.
AB - The autoimmune thyroid diseases (AITDs) are multifactorial disease which are caused by genetic susceptibility and environmental triggers. Various epidemiological and genetic techniques can be employed to study the genetic contribution to disease development. Most epidemiologic data support an important genetic contribution to the development of AITD. The genetic susceptibility to AITD involves several genes with varying effects. Some AITD susceptibility genes are most likely immune modifying genes which increase the susceptibility to autoimmunity in general (e.g. HLA, CTLA-4) while others may be thyroid-specific (e.g. thyroglobulin). These genes probably act in concert to increase the autoimmune reactions in susceptible individuals and direct them towards the thyroid.
KW - Autoimmune thyroid diseases
KW - Environmental triggers
KW - Genetic susceptibility
KW - Graves' disease
KW - Hashimoto's disease
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U2 - 10.1016/S1568-9972(02)00053-8
DO - 10.1016/S1568-9972(02)00053-8
M3 - Review article
C2 - 12848996
AN - SCOPUS:0043132433
SN - 1568-9972
VL - 1
SP - 198
EP - 204
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 4
ER -