TY - JOUR
T1 - Genetic determinants of virulence - Candida parapsilosis
AU - Singaravelu, Kumara
AU - Gácser, Attila
AU - Nosanchuk, Joshua D.
N1 - Funding Information:
AG was supported in part by OTKA NF 84006, NN100374 (ERA-Net PathoGenomics Program) and an EMBO Installation Grant . JN was supported in part by an award from the Irma T. Hirschl/Monique Weill-Caulier Trust.
PY - 2014/1
Y1 - 2014/1
N2 - The global epidemiology of fungal infections is changing. While overall, Candida albicans remains the most common pathogen; several institutions in Europe, Asia and South America have reported the rapid emergence to predominance of Candida parapsilosis. This mini-review examines the impact of gene deletions achieved in C. parapsilosis that have been published to date. The molecular approaches to gene disruption in C. parapsilosis and the molecularly characterized genes to date are reviewed. Similar to C. albicans, factors influencing virulence in C. parapsilosis include adherence, biofilm formation, lipid metabolism, and secretion of hydrolytic enzymes such as lipases, phospholipases and secreted aspartyl proteinases. Development of a targeted gene deletion method has enabled the identification of several unique aspects of C. parapsilosis genes that play a role in host-pathogen interactions - CpLIP1, CpLIP2, SAPP1a, SAPP1b, BCR1, RBT1, CpFAS2, OLE1, FIT-2.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).
AB - The global epidemiology of fungal infections is changing. While overall, Candida albicans remains the most common pathogen; several institutions in Europe, Asia and South America have reported the rapid emergence to predominance of Candida parapsilosis. This mini-review examines the impact of gene deletions achieved in C. parapsilosis that have been published to date. The molecular approaches to gene disruption in C. parapsilosis and the molecularly characterized genes to date are reviewed. Similar to C. albicans, factors influencing virulence in C. parapsilosis include adherence, biofilm formation, lipid metabolism, and secretion of hydrolytic enzymes such as lipases, phospholipases and secreted aspartyl proteinases. Development of a targeted gene deletion method has enabled the identification of several unique aspects of C. parapsilosis genes that play a role in host-pathogen interactions - CpLIP1, CpLIP2, SAPP1a, SAPP1b, BCR1, RBT1, CpFAS2, OLE1, FIT-2.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).
KW - Biofilm
KW - Candida parapsilosis
KW - Fatty acid biosynthesis
KW - Gene disruption
KW - Lipase
KW - Phospholipase
KW - Secreted aspartyl proteinases
KW - Virulence
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U2 - 10.1016/j.riam.2013.09.018
DO - 10.1016/j.riam.2013.09.018
M3 - Short survey
C2 - 24257473
AN - SCOPUS:84893744849
SN - 1130-1406
VL - 31
SP - 16
EP - 21
JO - Revista Iberoamericana de Micologia
JF - Revista Iberoamericana de Micologia
IS - 1
ER -