Genetic determinants of virulence - Candida parapsilosis

Kumara Singaravelu, Attila Gácser, Joshua D. Nosanchuk

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

The global epidemiology of fungal infections is changing. While overall, Candida albicans remains the most common pathogen; several institutions in Europe, Asia and South America have reported the rapid emergence to predominance of Candida parapsilosis. This mini-review examines the impact of gene deletions achieved in C. parapsilosis that have been published to date. The molecular approaches to gene disruption in C. parapsilosis and the molecularly characterized genes to date are reviewed. Similar to C. albicans, factors influencing virulence in C. parapsilosis include adherence, biofilm formation, lipid metabolism, and secretion of hydrolytic enzymes such as lipases, phospholipases and secreted aspartyl proteinases. Development of a targeted gene deletion method has enabled the identification of several unique aspects of C. parapsilosis genes that play a role in host-pathogen interactions - CpLIP1, CpLIP2, SAPP1a, SAPP1b, BCR1, RBT1, CpFAS2, OLE1, FIT-2.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalRevista Iberoamericana de Micologia
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Biofilm
  • Candida parapsilosis
  • Fatty acid biosynthesis
  • Gene disruption
  • Lipase
  • Phospholipase
  • Secreted aspartyl proteinases
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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