Genetic control of natural resistance to Trypanosoma rhodesiense: Transfer of resistance with bone marrow or spleen cells

H. C. Greenblatt, T. A. Potter, David L. Rosenstreich

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Inbred strains of mice differ greatly in their innate resistance to Trypanosoma rhodesiense, the etiologic agent of African sleeping sickness. BALB/c mice are very susceptible to this organism, whereas C57BL/6 mice are highly resistant. This difference is regulated by at least three distinct genes. An adoptive transfer study was performed in order to determine the tissue site of expression of these genes. Three inbred mouse strains (C57BL/6J, C3H.SW/SnJ, and BALB.B) that differ in resistance to T. rhodesiense, but are histocompatible at the H-2 locus, were used in the study. The adopive transfer of normal bone marrow cells from C57BL/6J (resistant) mice into X-irradiated BALB.B (susceptible) mice rendered the recipient mice resistant to a subsequent experimental challenge with T. rhodesiense. Conversely, the transfer of bone marrow cells from BALB.B mice into irradiated C57BL/6J mice rendered the latter mice susceptible. Resistance could also be adoptively transferred from C57BL/6J mice to a second susceptible strain, C3H.SW/SnJ, by using either bone marrow or spleen cells. These findings demonstrate that although multiple genes control innate resistance to T. rhodesiense, all or most of these genes appear to control the development or function of cells whose progenitors reside in the spleen and bone marrow.

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalJournal of Infectious Diseases
Volume151
Issue number5
StatePublished - 1985

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Trypanosoma brucei rhodesiense
Innate Immunity
Spleen
Bone Marrow
Inbred C57BL Mouse
Inbred Strains Mice
Bone Marrow Cells
Genes
African Trypanosomiasis
Adoptive Transfer
Stem Cells
Gene Expression

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Genetic control of natural resistance to Trypanosoma rhodesiense : Transfer of resistance with bone marrow or spleen cells. / Greenblatt, H. C.; Potter, T. A.; Rosenstreich, David L.

In: Journal of Infectious Diseases, Vol. 151, No. 5, 1985, p. 911-916.

Research output: Contribution to journalArticle

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