Genetic control of insulin receptors

A. E. Goldfeld, C. S. Rubin, T. W. Siegel, P. A. Shaw, S. G. Schiffer, S. Gluecksohn-Waelsch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin-binding activity was measured in hepatocyte suspensions and liver membrane preparations from newborn mice homozygous for a perinatal-lethal deletion at and around the albino locus in chromosome 7. Cell suspensions and membrane preparations from the mutant mice exhibited only 20-25% of the specific hormone-binding activity observed in comparable preparations from their homozygous normal and heterozygous littermates. The decrease in insulin-binding activity appears to be attributable to a decrease in the number of insulin receptor sites per cell rather than to a change in receptor affinity. Gene sequences deleted at and around the albino locus are therefore instrumental in the regulation of insulin receptor concentration rather than in coding for the insulin receptor itself. The results of the present studies extend the identification of the regulatory functions exerted by the genes around the albino locus of the mouse.

Original languageEnglish (US)
Pages (from-to)6359-6361
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number10 I
StatePublished - 1981

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Insulin Receptor
Suspensions
Insulin
Chromosomes, Human, Pair 7
Genes
Hepatocytes
Cell Membrane
Hormones
Membranes
Liver

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Goldfeld, A. E., Rubin, C. S., Siegel, T. W., Shaw, P. A., Schiffer, S. G., & Gluecksohn-Waelsch, S. (1981). Genetic control of insulin receptors. Proceedings of the National Academy of Sciences of the United States of America, 78(10 I), 6359-6361.

Genetic control of insulin receptors. / Goldfeld, A. E.; Rubin, C. S.; Siegel, T. W.; Shaw, P. A.; Schiffer, S. G.; Gluecksohn-Waelsch, S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 10 I, 1981, p. 6359-6361.

Research output: Contribution to journalArticle

Goldfeld, AE, Rubin, CS, Siegel, TW, Shaw, PA, Schiffer, SG & Gluecksohn-Waelsch, S 1981, 'Genetic control of insulin receptors', Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 10 I, pp. 6359-6361.
Goldfeld AE, Rubin CS, Siegel TW, Shaw PA, Schiffer SG, Gluecksohn-Waelsch S. Genetic control of insulin receptors. Proceedings of the National Academy of Sciences of the United States of America. 1981;78(10 I):6359-6361.
Goldfeld, A. E. ; Rubin, C. S. ; Siegel, T. W. ; Shaw, P. A. ; Schiffer, S. G. ; Gluecksohn-Waelsch, S. / Genetic control of insulin receptors. In: Proceedings of the National Academy of Sciences of the United States of America. 1981 ; Vol. 78, No. 10 I. pp. 6359-6361.
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