TY - JOUR
T1 - Genetic and stress influences on the prevalence of hypertension among hispanics/latinos in the hispanic community health study/study of latinos (HCHS/SOL)
AU - Preudhomme, Liana K.
AU - Gellman, Marc D.
AU - Franceschini, Nora
AU - Perreira, Krista M.
AU - Fernández-Rhodes, Lindsay E.
AU - Gallo, Linda C.
AU - Isasi, Carmen R.
AU - Smoller, Sylvia
AU - Castañeda, Sheila F.
AU - Daviglus, Martha
AU - Hutten, Christina
AU - Cooper, Richard S.
AU - Cai, Jianwen
AU - Schneiderman, Neil
AU - Llabre, Maria M.
N1 - Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Purpose: The current study examined the effects of chronic stress and a genetic risk score on the presence of hypertension and elevated systolic blood pressure and diastolic blood pressure among Hispanics/Latinos in the target population of Hispanic Community Health Study/Study of Latinos. Materials and Methods: Of the participants (N = 11,623) assessed during two clinic visits (Visit 1 2008–2013 & Visit 2 2014–2018), we analysed data from 7,429 adults (50.4% female), aged 18–74, who were genotyped and responded to chronic stress questionnaires. We calculated an unweighted genetic risk score using blood pressure increasing single nucleotide polymorphisms (SNPs) found to be generalisable to Hispanics/Latinos (10 SNPs). Linear and logistic regression models were used to estimate associations between chronic stress and genetic risk score and their interaction, with prevalent Visit 2 SBP or DBP, and hypertension, respectively. Models accounted for sampling weights, stratification, and cluster design. Results: Chronic stress (adjusted OR = 1.18, 95%CI:1.15,1.22) and hypertension genetic risk score (adjusted OR = 1.04, 95%CI:1.01,1.07) were significantly associated with prevalent hypertension, but there was no significant interaction between the chronic stress and genetic risk score on hypertension (p =.49). genetic risk score (b =.32, 95%CI:.08,.55, R 2 =.02) and chronic stress (b =.45, 95%CI:.19,.72, R 2 =.11) were related to DBP, with no significant interaction (p =.62). Genetic risk score (b =.42, 95%CI:.08,.76, R 2 =.01) and chronic stress (b =.80, 95%CI:.34,1.26, R 2 =.11) were also related to SBP, with no significant interaction (p =.51). Conclusion: Results demonstrate the utility of a genetic risk score for blood pressure and are consistent with literature suggesting chronic stress has a strong, direct association with elevated blood pressure among U.S. Hispanics/Latinos.
AB - Purpose: The current study examined the effects of chronic stress and a genetic risk score on the presence of hypertension and elevated systolic blood pressure and diastolic blood pressure among Hispanics/Latinos in the target population of Hispanic Community Health Study/Study of Latinos. Materials and Methods: Of the participants (N = 11,623) assessed during two clinic visits (Visit 1 2008–2013 & Visit 2 2014–2018), we analysed data from 7,429 adults (50.4% female), aged 18–74, who were genotyped and responded to chronic stress questionnaires. We calculated an unweighted genetic risk score using blood pressure increasing single nucleotide polymorphisms (SNPs) found to be generalisable to Hispanics/Latinos (10 SNPs). Linear and logistic regression models were used to estimate associations between chronic stress and genetic risk score and their interaction, with prevalent Visit 2 SBP or DBP, and hypertension, respectively. Models accounted for sampling weights, stratification, and cluster design. Results: Chronic stress (adjusted OR = 1.18, 95%CI:1.15,1.22) and hypertension genetic risk score (adjusted OR = 1.04, 95%CI:1.01,1.07) were significantly associated with prevalent hypertension, but there was no significant interaction between the chronic stress and genetic risk score on hypertension (p =.49). genetic risk score (b =.32, 95%CI:.08,.55, R 2 =.02) and chronic stress (b =.45, 95%CI:.19,.72, R 2 =.11) were related to DBP, with no significant interaction (p =.62). Genetic risk score (b =.42, 95%CI:.08,.76, R 2 =.01) and chronic stress (b =.80, 95%CI:.34,1.26, R 2 =.11) were also related to SBP, with no significant interaction (p =.51). Conclusion: Results demonstrate the utility of a genetic risk score for blood pressure and are consistent with literature suggesting chronic stress has a strong, direct association with elevated blood pressure among U.S. Hispanics/Latinos.
KW - Genetic risk
KW - Hispanic/Latino
KW - blood pressure
KW - chronic psychosocial stress
KW - hypertension
UR - http://www.scopus.com/inward/record.url?scp=85132958364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132958364&partnerID=8YFLogxK
U2 - 10.1080/08037051.2022.2091977
DO - 10.1080/08037051.2022.2091977
M3 - Article
C2 - 35762607
AN - SCOPUS:85132958364
SN - 0803-7051
VL - 31
SP - 155
EP - 163
JO - Blood Pressure
JF - Blood Pressure
IS - 1
ER -