@article{c2ff009cf73046f7a0f6e639ed05c638,
title = "Genetic and epigenetic studies of amyotrophic lateral sclerosis",
abstract = "The identification of genetic and epigenetic factors that are associated with an increased risk of developing amyotrophic lateral sclerosis (ALS), or that modify the age of onset or rate of progression, requires a multimodal research strategy, facilitated through international collaboration. The discovery of several ALS genes strongly linked to RNA biology, the proteasome pathway, and axonal transport suggest they have an important role in pathogenesis, but the immense complexity of these processes is also apparent. The increasing rate of genetic discoveries brings the hope of designing more targeted and efficacious therapies.",
keywords = "ALS, Epigenetic, Familial ALS, Genetic, Modifier genes",
author = "Ammar Al-Chalabi and Shin Kwak and Mark Mehler and Guy Rouleau and Teepu Siddique and Michael Strong and Leigh, {Peter Nigel}",
note = "Funding Information: The research leading to these results has received funding from the European Community {\textquoteleft} s Health Seventh Framework Programme. AAC receives salary support from the National Institute for Health Research (NIHR) Dementia Biomedical Research Unit at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London. The views expressed are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health. GAR holds the Canada Research Chair and a Jeanne-et-J-Louis-Levesque Chair for the Genetics of Brain Diseases. Funding Information: We thank the Motor Neurone Disease Association of Great Britain and Northern Ireland, the ALS Association, the Les Turner ALS Foundation, the ALS Society of Canada, and the Canadian Institutes of Health Research (CIHR) for support. Funding Information: A database of ALS genes (ALSoD) (9) with their associated phenotypes and a measure of their credibility is available at the World Federation of Neurology and European Network for the Cure of ALS (ENCALS) project website http://alsod.iop. kcl.ac.uk, generously supported by ALSA, ALS Therapy Alliance, MNDA and ALS Canada.",
year = "2013",
month = may,
doi = "10.3109/21678421.2013.778571",
language = "English (US)",
volume = "14",
pages = "44--52",
journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",
issn = "2167-8421",
publisher = "Informa Healthcare",
number = "SUPPL1",
}