Genetic abnormalities in sporadic parathyroid adenomas

Eitan Friedman, Allen E. Bale, Stephen J. Marx, Jeffrey A. Norton, Andrew Arnold, Thomas Tu, Gerald D. Aurbach, Allen M. Spiegel

Research output: Contribution to journalArticle

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Abstract

We analyzed genomic DNA from 43 sporadic benign parathyroid adenomas for rearrangements of the PTH gene and for point mutations of the H-ras (codons 12, 13, and 61), N-ras (codons 12, 13, and 61), and K-ras (codons 12 and 13) genes. One of 43 parathyroid adenomas showed a chromosome 11 rearrangement involving both the PTH gene on the short arm of chromosome 11 (at band p15) and a locus on the long arm (11q13). This rearrangement was indistinguishable from one that was previously described in a parathyroid adenoma by Arnold et al., indicating that this may be an important contributor to tumorigenesis in a small subset of patients with parathyroid adenoma. H-ras, K-ras, and N-ras oncogene activation by point mutation at codons 12, 13, or 61, known to occur in many tumors could not be detected in any parathyroid adenoma.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number2
StatePublished - Aug 1990
Externally publishedYes

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Parathyroid Neoplasms
Codon
Genes
Chromosomes
Chromosomes, Human, Pair 11
Point Mutation
Tumors
Chemical activation
ras Genes
Gene Rearrangement
DNA
Carcinogenesis
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Friedman, E., Bale, A. E., Marx, S. J., Norton, J. A., Arnold, A., Tu, T., ... Spiegel, A. M. (1990). Genetic abnormalities in sporadic parathyroid adenomas. Journal of Clinical Endocrinology and Metabolism, 71(2), 293-297.

Genetic abnormalities in sporadic parathyroid adenomas. / Friedman, Eitan; Bale, Allen E.; Marx, Stephen J.; Norton, Jeffrey A.; Arnold, Andrew; Tu, Thomas; Aurbach, Gerald D.; Spiegel, Allen M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 71, No. 2, 08.1990, p. 293-297.

Research output: Contribution to journalArticle

Friedman, E, Bale, AE, Marx, SJ, Norton, JA, Arnold, A, Tu, T, Aurbach, GD & Spiegel, AM 1990, 'Genetic abnormalities in sporadic parathyroid adenomas', Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 2, pp. 293-297.
Friedman E, Bale AE, Marx SJ, Norton JA, Arnold A, Tu T et al. Genetic abnormalities in sporadic parathyroid adenomas. Journal of Clinical Endocrinology and Metabolism. 1990 Aug;71(2):293-297.
Friedman, Eitan ; Bale, Allen E. ; Marx, Stephen J. ; Norton, Jeffrey A. ; Arnold, Andrew ; Tu, Thomas ; Aurbach, Gerald D. ; Spiegel, Allen M. / Genetic abnormalities in sporadic parathyroid adenomas. In: Journal of Clinical Endocrinology and Metabolism. 1990 ; Vol. 71, No. 2. pp. 293-297.
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